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- W2899223835 abstract "Bispecific antibodies that recruit and redirect T cells to attack tumor cells have tremendous potential for the treatment of various malignancies. In general, this class of therapeutics, known as CD3 bispecifics, promotes tumor cell killing by cross-linking a CD3 component of the T cell receptor complex with a tumor-associated antigen on the surface of the target cell. Importantly, this mechanism does not rely on a cognate interaction between the T cell receptor and a peptide:HLA complex, thereby circumventing HLA (human leukocyte antigen) restriction. Hence, CD3 bispecifics may find a key role in addressing tumors with low neoantigen content and/or low inflammation, and this class of therapeutics may productively combine with checkpoint blockade. A wide array of formats and optimization approaches has been developed, and a wave of CD3 bispecifics is proceeding into human clinical trials for a range of indications, with promising signs of therapeutic activity." @default.
- W2899223835 created "2018-11-09" @default.
- W2899223835 creator A5081789226 @default.
- W2899223835 creator A5088476266 @default.
- W2899223835 date "2019-01-27" @default.
- W2899223835 modified "2023-10-17" @default.
- W2899223835 title "Redirected T Cell Cytotoxicity in Cancer Therapy" @default.
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- W2899223835 doi "https://doi.org/10.1146/annurev-med-062617-035821" @default.
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