FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899224470> ?p ?o ?g. }

• W2899224470 endingPage "e0006814" @default.
• W2899224470 startingPage "e0006814" @default.
• W2899224470 abstract "Background The effectiveness of anti-parasite treatment with benznidazole in the chronic Chagas disease (ChD) remains uncertain. We evaluated, using data from the NIH-sponsored SaMi-Trop prospective cohort study, if previous treatment with benznidazole is associated with lower mortality, less advanced cardiac disease and lower parasitemia in patients with chronic ChD. Methods The study enrolled 1,959 ChD patients and abnormal electrocardiogram (ECG) from in 21 remote towns in Brazil. A total of 1,813 patients were evaluated at baseline and after two years of follow-up. Those who received at least one course of benznidazole were classified as treated group (TrG = 493) and those who were never treated as control group (CG = 1,320). The primary outcome was death after two-year follow-up; the secondary outcomes were presence at the baseline of major ChD-associated ECG abnormalities, NT-ProBNP levels suggestive of heart failure, and PCR positivity. Results Mortality after two years was 6.3%; it was lower in the TrG (2.8%) than the CG (7.6%); adjusted OR: 0.37 (95%CI: 0.21;0.63). The ECG abnormalities typical for ChD and high age-adjusted NT-ProBNP levels suggestive of heart failure were lower in the TrG than the CG, OR: 0.35 [CI: 0.23;0.53]. The TrG had significantly lower rates of PCR positivity, OR: 0.35 [CI: 0.27;0.45]. Conclusion Patients previously treated with benznidazole had significantly reduced parasitemia, a lower prevalence of markers of severe cardiomyopathy, and lower mortality after two years of follow-up. If used in the early phases, benznidazole treatment may improve clinical and parasitological outcomes in patients with chronic ChD. Trial registration ClinicalTrials.gov, Trial registration: NCT02646943." @default.
• W2899224470 created "2018-11-09" @default.
• W2899224470 creator A5006273714 @default.
• W2899224470 creator A5006950796 @default.
• W2899224470 creator A5007921652 @default.
• W2899224470 creator A5008405795 @default.
• W2899224470 creator A5018855983 @default.
• W2899224470 creator A5030857975 @default.
• W2899224470 creator A5055327874 @default.
• W2899224470 creator A5061924893 @default.
• W2899224470 creator A5062975649 @default.
• W2899224470 creator A5067910047 @default.
• W2899224470 creator A5071061513 @default.
• W2899224470 creator A5072162738 @default.
• W2899224470 creator A5087237834 @default.
• W2899224470 date "2018-11-01" @default.
• W2899224470 modified "2023-10-07" @default.
• W2899224470 title "Beneficial effects of benznidazole in Chagas disease: NIH SaMi-Trop cohort study" @default.
• W2899224470 cites W1275135383 @default.
• W2899224470 cites W1667622441 @default.
• W2899224470 cites W1928866946 @default.
• W2899224470 cites W2058484100 @default.
• W2899224470 cites W2063503143 @default.
• W2899224470 cites W2068908428 @default.
• W2899224470 cites W2086913931 @default.
• W2899224470 cites W2095126957 @default.
• W2899224470 cites W2098696423 @default.
• W2899224470 cites W2099769151 @default.
• W2899224470 cites W2100932180 @default.
• W2899224470 cites W2114546645 @default.
• W2899224470 cites W2117846137 @default.
• W2899224470 cites W2125581925 @default.
• W2899224470 cites W2137589565 @default.
• W2899224470 cites W2171882431 @default.
• W2899224470 cites W2212701647 @default.
• W2899224470 cites W2299310792 @default.
• W2899224470 cites W2322471444 @default.
• W2899224470 cites W2346130406 @default.
• W2899224470 cites W2589928324 @default.
• W2899224470 cites W2591537128 @default.
• W2899224470 cites W2625002977 @default.
• W2899224470 cites W2784228551 @default.
• W2899224470 cites W2911339676 @default.
• W2899224470 cites W4235938477 @default.
• W2899224470 cites W4299960106 @default.
• W2899224470 doi "https://doi.org/10.1371/journal.pntd.0006814" @default.
• W2899224470 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6211620" @default.
• W2899224470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30383777" @default.
• W2899224470 hasPublicationYear "2018" @default.
• W2899224470 type Work @default.
• W2899224470 sameAs 2899224470 @default.
• W2899224470 citedByCount "52" @default.
• W2899224470 countsByYear W28992244702019 @default.
• W2899224470 countsByYear W28992244702020 @default.
• W2899224470 countsByYear W28992244702021 @default.
• W2899224470 countsByYear W28992244702022 @default.
• W2899224470 countsByYear W28992244702023 @default.
• W2899224470 crossrefType "journal-article" @default.
• W2899224470 hasAuthorship W2899224470A5006273714 @default.
• W2899224470 hasAuthorship W2899224470A5006950796 @default.
• W2899224470 hasAuthorship W2899224470A5007921652 @default.
• W2899224470 hasAuthorship W2899224470A5008405795 @default.
• W2899224470 hasAuthorship W2899224470A5018855983 @default.
• W2899224470 hasAuthorship W2899224470A5030857975 @default.
• W2899224470 hasAuthorship W2899224470A5055327874 @default.
• W2899224470 hasAuthorship W2899224470A5061924893 @default.
• W2899224470 hasAuthorship W2899224470A5062975649 @default.
• W2899224470 hasAuthorship W2899224470A5067910047 @default.
• W2899224470 hasAuthorship W2899224470A5071061513 @default.
• W2899224470 hasAuthorship W2899224470A5072162738 @default.
• W2899224470 hasAuthorship W2899224470A5087237834 @default.
• W2899224470 hasBestOaLocation W28992244701 @default.
• W2899224470 hasConcept C112418997 @default.
• W2899224470 hasConcept C126322002 @default.
• W2899224470 hasConcept C136764020 @default.
• W2899224470 hasConcept C188816634 @default.
• W2899224470 hasConcept C201903717 @default.
• W2899224470 hasConcept C203014093 @default.
• W2899224470 hasConcept C2775867548 @default.
• W2899224470 hasConcept C2776171842 @default.
• W2899224470 hasConcept C2777625466 @default.
• W2899224470 hasConcept C2778048844 @default.
• W2899224470 hasConcept C2778198053 @default.
• W2899224470 hasConcept C2778371730 @default.
• W2899224470 hasConcept C41008148 @default.
• W2899224470 hasConcept C71924100 @default.
• W2899224470 hasConcept C71928629 @default.
• W2899224470 hasConcept C72563966 @default.
• W2899224470 hasConcept C90924648 @default.
• W2899224470 hasConceptScore W2899224470C112418997 @default.
• W2899224470 hasConceptScore W2899224470C126322002 @default.
• W2899224470 hasConceptScore W2899224470C136764020 @default.
• W2899224470 hasConceptScore W2899224470C188816634 @default.
• W2899224470 hasConceptScore W2899224470C201903717 @default.
• W2899224470 hasConceptScore W2899224470C203014093 @default.
• W2899224470 hasConceptScore W2899224470C2775867548 @default.
• W2899224470 hasConceptScore W2899224470C2776171842 @default.
• W2899224470 hasConceptScore W2899224470C2777625466 @default.

• next