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- W2899243338 abstract "Objectives: We tested our hypothesis that a valsartan/cilnidipine combination would reduce and optimize nocturnal home systolic blood pressure (HSBP), assessed by information and communication technology (ICT)-based home BP monitoring device, compared to a valsartan/hydrochlorothiazide (HCTZ) combination in patients with morning hypertension, defined as morning SBP ≥135 mmHg or diastolic BP ≥85 mmHg. Methods: This study was a 8-week prospective, multicenter, randomized, open-label clinical trial conducted in Japan. Patients were asked to measure nocturnal HSBP over 3 nights prior to the study randomization and the end of treatment. Eligible patients were randomly allocated to either the valsartan/cilnidipine (80/10 mg) or valsartan/HCTZ (80/12.5 mg) combination groups. Results: Forty-eight patients (mean 69.6 years, 39.6 % male) and fifty patients (mean 67.0 years, 46.0 % male) were assessed in the valsartan/cilnidipine group and the valsartan/HCTZ group, and their baseline nocturnal HSBP were 124.3 ± 15.6 and 125.8 ± 15.2 mmHg, respectively (p = 0.597). Although nocturnal HSBP was significantly reduced from baseline in both treatment groups, the valsartan/HCTZ group significantly reduced nocturnal HSBP compared to the valsartan/cilnidipine group (−5.0 vs. − 10.0 mmHg, p = 0.035). However, the significant interaction between treatment groups concerning the baseline nocturnal HSBP level and the change in nocturnal HSBP was observed (p = 0.047), which indicated that the valsartan/cilnidipine combination did not reduce nocturnal HSBP in patients with already controlled, while it could reduce nocturnal HSBP in patients with uncontrolled. Conclusion: Valsartan/cilnidipine combination could reduce and optimize nocturnal HSBP levels more effectively than the valsartan/HCTZ combination." @default.
- W2899243338 created "2018-11-09" @default.
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- W2899243338 date "2018-10-01" @default.
- W2899243338 modified "2023-09-26" @default.
- W2899243338 title "A1814 Comparative Effects of Valsartan plus Either Cilnidipine or Hydrochlorothiazide on Nocturnal Home Blood Pressure in Patients with Morning Hypertension" @default.
- W2899243338 doi "https://doi.org/10.1097/01.hjh.0000548452.05861.a9" @default.
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