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- W2899245502 abstract "Infant vocalizations are one of the most fundament and innate forms of behavior throughout avian and mammalian orders. They have a critical role in motivating parental care and through this contribute significantly to fitness and reproductive success. Dysregulation of these vocalizations has been reported to predict risk of central nervous system pathologies such as hypoxia, meningitis or autism spectrum disorder. Here we have used the expanded BXD family of mice, and a diallel cross between DBA/2J and C57BL/6J parental strains, to begin the process of genetically dissecting the numerous facets of infant vocalizations. We calculate heritability, estimate the role of parent-of-origin effects, and identify novel quantitative trait loci (QTLs) that control USVs on postnatal days 7, 8, and 9; a stage that closely matches human infants at birth. Heritability estimates for the number and frequency of calls are low, suggesting that these traits are under high selective pressure. In contrast, duration and amplitude of calls have higher heritabilities, indicating lower selection, or their importance for kin recognition. We find suggestive evidence that amplitude of infant calls is dependent on the maternal genotype, independent of shared genetic variants. Finally, we identify two loci on Chrs 2 and 14 influencing call frequency, and a third locus on Chr 8 influencing the amplitude of vocalizations. All three loci contain strong candidate genes that merit further analysis. Understanding the genetic control of infant vocalizations is not just important for understanding the evolution of parent-offspring interactions, but also in understanding the earliest innate behaviors, the development of parent-offspring relations, and the early identification of behavioral abnormalities. Keywords: Infant ultrasonic vocalizations; quantitative trait loci; heritability; parent-of-origin effects; crying; genetic dissection; BXD; USV" @default.
- W2899245502 created "2018-11-09" @default.
- W2899245502 creator A5000902987 @default.
- W2899245502 creator A5016499365 @default.
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- W2899245502 creator A5030429211 @default.
- W2899245502 creator A5032436971 @default.
- W2899245502 creator A5035796668 @default.
- W2899245502 creator A5037829890 @default.
- W2899245502 creator A5040313272 @default.
- W2899245502 date "2018-10-29" @default.
- W2899245502 modified "2023-10-11" @default.
- W2899245502 title "Born to Cry: A Genetic Dissection of Infant Vocalization" @default.
- W2899245502 cites W1184110635 @default.
- W2899245502 cites W1459058273 @default.
- W2899245502 cites W1487037301 @default.
- W2899245502 cites W1490161904 @default.
- W2899245502 cites W1575291820 @default.
- W2899245502 cites W1718591779 @default.
- W2899245502 cites W1905388141 @default.
- W2899245502 cites W1945247312 @default.
- W2899245502 cites W1965678028 @default.
- W2899245502 cites W1969302660 @default.
- W2899245502 cites W1971341839 @default.
- W2899245502 cites W1971676092 @default.
- W2899245502 cites W1971923126 @default.
- W2899245502 cites W1973882467 @default.
- W2899245502 cites W1974565082 @default.
- W2899245502 cites W1975305972 @default.
- W2899245502 cites W1978337367 @default.
- W2899245502 cites W1978600275 @default.
- W2899245502 cites W1979950256 @default.
- W2899245502 cites W1980168725 @default.
- W2899245502 cites W1983867657 @default.
- W2899245502 cites W1987330539 @default.
- W2899245502 cites W1988851344 @default.
- W2899245502 cites W1992667293 @default.
- W2899245502 cites W1998767819 @default.
- W2899245502 cites W2001258322 @default.
- W2899245502 cites W2006296034 @default.
- W2899245502 cites W2012376770 @default.
- W2899245502 cites W2012717802 @default.
- W2899245502 cites W2012724657 @default.
- W2899245502 cites W2013928806 @default.
- W2899245502 cites W2022119609 @default.
- W2899245502 cites W2022567100 @default.
- W2899245502 cites W2022911099 @default.
- W2899245502 cites W2033787548 @default.
- W2899245502 cites W2034192229 @default.
- W2899245502 cites W2034608799 @default.
- W2899245502 cites W2034842027 @default.
- W2899245502 cites W2042076636 @default.
- W2899245502 cites W2044220354 @default.
- W2899245502 cites W2050561451 @default.
- W2899245502 cites W2053434663 @default.
- W2899245502 cites W2055370862 @default.
- W2899245502 cites W2064092044 @default.
- W2899245502 cites W2068321836 @default.
- W2899245502 cites W2070508230 @default.
- W2899245502 cites W2070989829 @default.
- W2899245502 cites W2071065596 @default.
- W2899245502 cites W2073103827 @default.
- W2899245502 cites W2074154809 @default.
- W2899245502 cites W2077849899 @default.
- W2899245502 cites W2085583998 @default.
- W2899245502 cites W2097260914 @default.
- W2899245502 cites W2101010807 @default.
- W2899245502 cites W2102504839 @default.
- W2899245502 cites W2103017472 @default.
- W2899245502 cites W2106145814 @default.
- W2899245502 cites W2106927517 @default.
- W2899245502 cites W2108228680 @default.
- W2899245502 cites W2109402846 @default.
- W2899245502 cites W2117352607 @default.
- W2899245502 cites W2121998056 @default.
- W2899245502 cites W2126156206 @default.
- W2899245502 cites W2131332229 @default.
- W2899245502 cites W2139651996 @default.
- W2899245502 cites W2143418585 @default.
- W2899245502 cites W2153617971 @default.
- W2899245502 cites W2154476663 @default.
- W2899245502 cites W2159482845 @default.
- W2899245502 cites W2160242809 @default.
- W2899245502 cites W2169492128 @default.
- W2899245502 cites W2171195450 @default.
- W2899245502 cites W2172030748 @default.
- W2899245502 cites W2184750625 @default.
- W2899245502 cites W2240108082 @default.
- W2899245502 cites W2289520089 @default.
- W2899245502 cites W2291551283 @default.
- W2899245502 cites W2296912573 @default.
- W2899245502 cites W2312921509 @default.
- W2899245502 cites W2321589279 @default.
- W2899245502 cites W2442033574 @default.
- W2899245502 cites W2468802625 @default.
- W2899245502 cites W2518377536 @default.
- W2899245502 cites W2522286455 @default.
- W2899245502 cites W2532373937 @default.
- W2899245502 cites W2582561176 @default.
- W2899245502 cites W2610748997 @default.