Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899248497> ?p ?o ?g. }
- W2899248497 abstract "Abstract Infections and thrombus formation are major concerns for the success of blood‐contacting medical devices. Antimicrobial coatings based on antimicrobial peptides (AMPs) are described as promising strategies to fight biomaterial‐associated infections. However, their efficiency in the presence of plasma and their effect on platelets adhesion/activation, essential for blood contact applications, is not known. In this work, the AMP cecropin–melittin (CM) is covalently immobilized onto polyurethane (PU) films envisaging a coating for intravascular catheters. Immobilization is done by dip‐coating of a layer of gold nanoparticles (Au NPs) functionalized with NH 2 and COOH terminated polyethylene glycol (PEG). Surfaces characterized using scanning electron microscopy (SEM), X‐ray photoelectron spectroscopy (XPS), quartz crystal microbalance with dissipation (QCM‐D), and colorimetric assays reveal a stable and homogeneous coating distribution. CM coating significantly reduces Staphylococcus epidermidis adhesion to PU films (≈80% in PBS). Its bactericidal activity is not affected in the presence of 1% human plasma (hPlasma) proteins with 65% reduction on viable bacteria comparing to PU. Moreover, CM coating is able to prevent platelet adhesion/activation to PU films (≈95% in PBS). This effect is also observed when surfaces are precoated with hPlasma. Overall, the developed antimicrobial coating demonstrates great potential to prevent bacterial infections on PU devices without instigating platelet adhesion/activation." @default.
- W2899248497 created "2018-11-09" @default.
- W2899248497 creator A5006690381 @default.
- W2899248497 creator A5012466070 @default.
- W2899248497 creator A5041673356 @default.
- W2899248497 creator A5046768657 @default.
- W2899248497 creator A5054475578 @default.
- W2899248497 creator A5076001987 @default.
- W2899248497 creator A5076705434 @default.
- W2899248497 creator A5079157383 @default.
- W2899248497 creator A5088824044 @default.
- W2899248497 date "2018-10-29" @default.
- W2899248497 modified "2023-10-18" @default.
- W2899248497 title "Cecropin-Melittin Functionalized Polyurethane Surfaces Prevent <i>Staphylococcus epidermidis</i> Adhesion without Inducing Platelet Adhesion and Activation" @default.
- W2899248497 cites W1972488241 @default.
- W2899248497 cites W1975821399 @default.
- W2899248497 cites W1989734247 @default.
- W2899248497 cites W2002368526 @default.
- W2899248497 cites W2007817492 @default.
- W2899248497 cites W2014111920 @default.
- W2899248497 cites W2019223142 @default.
- W2899248497 cites W2021846625 @default.
- W2899248497 cites W2025983646 @default.
- W2899248497 cites W2035304534 @default.
- W2899248497 cites W2037025669 @default.
- W2899248497 cites W2048808551 @default.
- W2899248497 cites W2051106992 @default.
- W2899248497 cites W2051844263 @default.
- W2899248497 cites W2056332997 @default.
- W2899248497 cites W2059154739 @default.
- W2899248497 cites W2060815224 @default.
- W2899248497 cites W2066213947 @default.
- W2899248497 cites W2067018811 @default.
- W2899248497 cites W2073166891 @default.
- W2899248497 cites W2077643998 @default.
- W2899248497 cites W2084894566 @default.
- W2899248497 cites W2095211254 @default.
- W2899248497 cites W2099356975 @default.
- W2899248497 cites W2114225171 @default.
- W2899248497 cites W2115029038 @default.
- W2899248497 cites W2155959569 @default.
- W2899248497 cites W2168414582 @default.
- W2899248497 cites W2168620923 @default.
- W2899248497 cites W2169459642 @default.
- W2899248497 cites W2193465684 @default.
- W2899248497 cites W2251448886 @default.
- W2899248497 cites W2287019289 @default.
- W2899248497 cites W2306508187 @default.
- W2899248497 cites W2313492186 @default.
- W2899248497 cites W2336822846 @default.
- W2899248497 cites W2340145851 @default.
- W2899248497 cites W2394564069 @default.
- W2899248497 cites W2397335709 @default.
- W2899248497 cites W2432443528 @default.
- W2899248497 cites W2476635813 @default.
- W2899248497 cites W2494552981 @default.
- W2899248497 cites W2552279711 @default.
- W2899248497 cites W2574929177 @default.
- W2899248497 cites W2582834719 @default.
- W2899248497 cites W2587458947 @default.
- W2899248497 cites W2607404265 @default.
- W2899248497 cites W2612143811 @default.
- W2899248497 cites W4210968711 @default.
- W2899248497 doi "https://doi.org/10.1002/admi.201801390" @default.
- W2899248497 hasPublicationYear "2018" @default.
- W2899248497 type Work @default.
- W2899248497 sameAs 2899248497 @default.
- W2899248497 citedByCount "12" @default.
- W2899248497 countsByYear W28992484972019 @default.
- W2899248497 countsByYear W28992484972020 @default.
- W2899248497 countsByYear W28992484972021 @default.
- W2899248497 countsByYear W28992484972022 @default.
- W2899248497 crossrefType "journal-article" @default.
- W2899248497 hasAuthorship W2899248497A5006690381 @default.
- W2899248497 hasAuthorship W2899248497A5012466070 @default.
- W2899248497 hasAuthorship W2899248497A5041673356 @default.
- W2899248497 hasAuthorship W2899248497A5046768657 @default.
- W2899248497 hasAuthorship W2899248497A5054475578 @default.
- W2899248497 hasAuthorship W2899248497A5076001987 @default.
- W2899248497 hasAuthorship W2899248497A5076705434 @default.
- W2899248497 hasAuthorship W2899248497A5079157383 @default.
- W2899248497 hasAuthorship W2899248497A5088824044 @default.
- W2899248497 hasConcept C127413603 @default.
- W2899248497 hasConcept C150394285 @default.
- W2899248497 hasConcept C159985019 @default.
- W2899248497 hasConcept C171250308 @default.
- W2899248497 hasConcept C178790620 @default.
- W2899248497 hasConcept C185592680 @default.
- W2899248497 hasConcept C192562407 @default.
- W2899248497 hasConcept C203014093 @default.
- W2899248497 hasConcept C2776964284 @default.
- W2899248497 hasConcept C2777949923 @default.
- W2899248497 hasConcept C2779489039 @default.
- W2899248497 hasConcept C2779578285 @default.
- W2899248497 hasConcept C2781448156 @default.
- W2899248497 hasConcept C3018697912 @default.
- W2899248497 hasConcept C42360764 @default.
- W2899248497 hasConcept C523546767 @default.
- W2899248497 hasConcept C54355233 @default.
- W2899248497 hasConcept C71924100 @default.