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- W2899284983 abstract "Bacterial infections with severely damaging consequences are serious threats to the public healthcare system. A pH-sensitive theranostic system was fabricated for targeting bacteria with fluorescence imaging and dual-modal antimicrobial therapy (cationic and photodynamic therapies). Poly(poly(ethylene glycol) methyl ether methacrylate)-b-poly(2-(diisopropylamino) ethyl methacrylate-co-2-hydroxyethyl methacrylate)-chlorin e6 (PPEGMA-b-P(DPA-co-HEMA)-Ce6) was synthesized via reversible addition–fragmentation chain transfer (RAFT) polymerization and post-modification. The self-assembled PPEGMA-b-P(DPA-co-HEMA)-Ce6 nanoparticles (NPs) with a mean diameter of about 78 nm and polydispersity index of 0.27 were obtained through the dialysis method. The surface potential of PPEGMA-b-P(DPA-co-HEMA)-Ce6 NPs can undergo changes from negative (−1.45 mV) at pH 7.4 to highly positive (+11.6 mV) at pH 6.0, as characterized by the zetasizer. The extent of interaction between the PPEGMA-b-P(DPA-co-HEMA)-Ce6 NPs and bacteria (Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus)), evaluated by flow cytometry and confocal microscopy, was rather limited at pH 7.4. However, the PPEGMA-b-P(DPA-co-HEMA)-Ce6 NPs bind bacteria effectively and achieve fluorescence bacterial imaging at pH 6.0. Furthermore, the growth curve of bacteria showed that the PPEGMA-b-P(DPA-co-HEMA)-Ce6 NPs can achieve good antimicrobial efficacy through combined cationic and photodynamic therapies under acidic pH conditions (pH 6.0)." @default.
- W2899284983 created "2018-11-09" @default.
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- W2899284983 date "2018-10-29" @default.
- W2899284983 modified "2023-10-16" @default.
- W2899284983 title "pH-Sensitive Theranostic Nanoparticles for Targeting Bacteria with Fluorescence Imaging and Dual-Modal Antimicrobial Therapy" @default.
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- W2899284983 doi "https://doi.org/10.1021/acsanm.8b01401" @default.
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