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- W2899293472 abstract "A new series of quinazolinone hybrid molecules containing coumarin, furan, 1,2,4-triazole and 1,2,4-thiadiazole rings was designed, synthesized, and screened for their urease inhibition activities. All newly synthesized compounds showed outstanding urease inhibitory potentials with IC50 values ranging between 1.26 ± 0.07 and 7.35 ± 0.31 μg/mL. Among the series, coumarin derivatives (10a-d) exhibited the best inhibitory effect against urease in the range of IC50 = 1.26 ± 0.07 to 1.82 ± 0.10 μg/mL, when compared to standard urease inhibitors such as acetohydroxamic acid and thiourea (IC50 = 21.05 ± 0.96 and 15.08 ± 0.71 μg/mL, respectively). Molecular docking studies were also performed to analyze the binding mode of compound 10b, and supported the experimental results." @default.
- W2899293472 created "2018-11-09" @default.
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- W2899293472 date "2018-10-30" @default.
- W2899293472 modified "2023-10-16" @default.
- W2899293472 title "Synthesis of some novel quinazolin-4(3<i>H</i>)-one hybrid molecules as potent urease inhibitors" @default.
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- W2899293472 doi "https://doi.org/10.1002/ardp.201800182" @default.
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