Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899298907> ?p ?o ?g. }
- W2899298907 abstract "ABSTRACT High accuracy next-generation DNA sequencing promises a paradigm shift in early cancer detection by enabling the identification of mutant cancer molecules in minimally-invasive body fluid samples. We demonstrate 80% sensitivity for ovarian cancer detection using ultra-accurate Duplex Sequencing to identify TP53 mutations in uterine lavage. However, in addition to tumor DNA, we also detect low frequency TP53 mutations in nearly all lavages from women with and without cancer. These mutations increase with age and share the selection traits of clonal TP53 mutations commonly found in human tumors. We show that low frequency TP53 mutations exist in multiple healthy tissues, from newborn to centenarian, and progressively increase in abundance and pathogenicity with older age across tissue types. Our results illustrate that subclonal cancer evolutionary processes are a ubiquitous part of normal human aging and great care must be taken to distinguish tumor-derived, from age-associated mutations in high sensitivity clinical cancer diagnostics." @default.
- W2899298907 created "2018-11-09" @default.
- W2899298907 creator A5010673322 @default.
- W2899298907 creator A5014595319 @default.
- W2899298907 creator A5017891116 @default.
- W2899298907 creator A5019584888 @default.
- W2899298907 creator A5022774722 @default.
- W2899298907 creator A5024574476 @default.
- W2899298907 creator A5028113408 @default.
- W2899298907 creator A5033302504 @default.
- W2899298907 creator A5040861348 @default.
- W2899298907 creator A5047595244 @default.
- W2899298907 creator A5054082017 @default.
- W2899298907 creator A5069352517 @default.
- W2899298907 creator A5072939873 @default.
- W2899298907 creator A5073544981 @default.
- W2899298907 creator A5074017962 @default.
- W2899298907 creator A5079598741 @default.
- W2899298907 date "2018-11-04" @default.
- W2899298907 modified "2023-10-18" @default.
- W2899298907 title "Ultra-sensitive sequencing for cancer detection reveals progressive clonal selection in normal tissue over a century of human lifespan" @default.
- W2899298907 cites W1758302002 @default.
- W2899298907 cites W1907806866 @default.
- W2899298907 cites W1956871134 @default.
- W2899298907 cites W1990508187 @default.
- W2899298907 cites W1992826811 @default.
- W2899298907 cites W2008191042 @default.
- W2899298907 cites W2011645981 @default.
- W2899298907 cites W2027735722 @default.
- W2899298907 cites W2083957968 @default.
- W2899298907 cites W2085283923 @default.
- W2899298907 cites W2101412130 @default.
- W2899298907 cites W2110523744 @default.
- W2899298907 cites W2111900617 @default.
- W2899298907 cites W2123696077 @default.
- W2899298907 cites W2126816979 @default.
- W2899298907 cites W2143197030 @default.
- W2899298907 cites W2149858388 @default.
- W2899298907 cites W2162217976 @default.
- W2899298907 cites W2167824256 @default.
- W2899298907 cites W2173818354 @default.
- W2899298907 cites W2220812108 @default.
- W2899298907 cites W2294395959 @default.
- W2899298907 cites W2346990949 @default.
- W2899298907 cites W2511116391 @default.
- W2899298907 cites W2570618306 @default.
- W2899298907 cites W2580698996 @default.
- W2899298907 cites W2586862787 @default.
- W2899298907 cites W2612851374 @default.
- W2899298907 cites W2726121306 @default.
- W2899298907 cites W2782426754 @default.
- W2899298907 cites W2789711546 @default.
- W2899298907 cites W2789811819 @default.
- W2899298907 cites W2792407191 @default.
- W2899298907 cites W2885069342 @default.
- W2899298907 cites W2889646458 @default.
- W2899298907 cites W2891750848 @default.
- W2899298907 cites W2897064819 @default.
- W2899298907 cites W2898758713 @default.
- W2899298907 cites W2910453686 @default.
- W2899298907 cites W4253734173 @default.
- W2899298907 doi "https://doi.org/10.1101/457291" @default.
- W2899298907 hasPublicationYear "2018" @default.
- W2899298907 type Work @default.
- W2899298907 sameAs 2899298907 @default.
- W2899298907 citedByCount "1" @default.
- W2899298907 countsByYear W28992989072019 @default.
- W2899298907 crossrefType "posted-content" @default.
- W2899298907 hasAuthorship W2899298907A5010673322 @default.
- W2899298907 hasAuthorship W2899298907A5014595319 @default.
- W2899298907 hasAuthorship W2899298907A5017891116 @default.
- W2899298907 hasAuthorship W2899298907A5019584888 @default.
- W2899298907 hasAuthorship W2899298907A5022774722 @default.
- W2899298907 hasAuthorship W2899298907A5024574476 @default.
- W2899298907 hasAuthorship W2899298907A5028113408 @default.
- W2899298907 hasAuthorship W2899298907A5033302504 @default.
- W2899298907 hasAuthorship W2899298907A5040861348 @default.
- W2899298907 hasAuthorship W2899298907A5047595244 @default.
- W2899298907 hasAuthorship W2899298907A5054082017 @default.
- W2899298907 hasAuthorship W2899298907A5069352517 @default.
- W2899298907 hasAuthorship W2899298907A5072939873 @default.
- W2899298907 hasAuthorship W2899298907A5073544981 @default.
- W2899298907 hasAuthorship W2899298907A5074017962 @default.
- W2899298907 hasAuthorship W2899298907A5079598741 @default.
- W2899298907 hasBestOaLocation W28992989071 @default.
- W2899298907 hasConcept C121608353 @default.
- W2899298907 hasConcept C2776759703 @default.
- W2899298907 hasConcept C2779403534 @default.
- W2899298907 hasConcept C2780427987 @default.
- W2899298907 hasConcept C502942594 @default.
- W2899298907 hasConcept C51679486 @default.
- W2899298907 hasConcept C54355233 @default.
- W2899298907 hasConcept C552990157 @default.
- W2899298907 hasConcept C70721500 @default.
- W2899298907 hasConcept C86803240 @default.
- W2899298907 hasConceptScore W2899298907C121608353 @default.
- W2899298907 hasConceptScore W2899298907C2776759703 @default.
- W2899298907 hasConceptScore W2899298907C2779403534 @default.
- W2899298907 hasConceptScore W2899298907C2780427987 @default.
- W2899298907 hasConceptScore W2899298907C502942594 @default.