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- W2899304319 abstract "In this longitudinal pilot study, we investigated how manual dexterity recovery was related to corticospinal tract (CST) injury and excitability, in six patients undergoing conventional rehabilitation. Key components of manual dexterity, namely finger force control, finger tapping rate and independence of finger movements, were quantified. Structural MRI was obtained to calculate CST lesion load. CST excitability was assessed by measuring rest motor threshold (RMT) and the amplitude of motor evoked potentials (MEPs) using transcranial magnetic stimulation (TMS). Measurements were obtained at two weeks, three and six months post-stroke. At six months post-stroke, complete recovery of hand gross motor impairment (i.e., maximal Fugl-Meyer score for hand) had occurred in three patients and four patients had recovered ability to accurately control finger force. However, tapping rate and independence of finger movements remained impaired in all six patients at six months. Recovery in hand gross motor impairment and finger force control occurred in patients with smaller CST lesion load and almost complete recovery of CST excitability, although RMT or MEP size remained slightly altered in the stroke-affected hemisphere compared to the unaffected hemisphere. The two patients with poorest recovery showed persistent absence of MEPs and greatest structural injury to CST. The findings support good motor recovery being overall correlated with smaller CST lesion, and with almost complete recovery of CST excitability. However, impairment of manual dexterity persisted despite recovery in gross hand movements and grasping abilities, suggesting involvement of additional brain structures for fine manual tasks." @default.
- W2899304319 created "2018-11-09" @default.
- W2899304319 creator A5004410810 @default.
- W2899304319 creator A5008021208 @default.
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- W2899304319 creator A5026157924 @default.
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- W2899304319 creator A5057732280 @default.
- W2899304319 creator A5069998513 @default.
- W2899304319 creator A5071564209 @default.
- W2899304319 creator A5076542513 @default.
- W2899304319 date "2019-04-01" @default.
- W2899304319 modified "2023-10-05" @default.
- W2899304319 title "Individual recovery profiles of manual dexterity, and relation to corticospinal lesion load and excitability after stroke –a longitudinal pilot study" @default.
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