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- W289930841 abstract "At one time it was believed that insulin and other polypeptide hormones did not enter the interior of target cells. Electron microscope autoradiographic and other types of studies have recently indicated, however, that insulin enters the interior of lymphocytes in vitro and hepatocytes in vivo. This entry is time dependent and presumably is mediated by insulin receptors located on the plasma membrane of these cells. Electron microscope autoradiographs reveal that insulin, after entry into lymphocytes and hepatocytes, interacts with specific intracellular organelles, including the endoplasmic reticulum and nuclear envelope in both cell types, and the Golgi in hepatocytes. This interaction of insulin with intracellular organelles may represent one mechanism whereby insulin regulates intracellular functions. In addition, there is a vesicular uptake system for insulin in hepatocytes that degrades insulin and then deposits the degraded hormone into the bile." @default.
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- W289930841 date "1981-01-01" @default.
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- W289930841 title "ENTRY OF INSULIN INTO TARGET CELLS IN VITRO AND IN VIVO" @default.
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- W289930841 doi "https://doi.org/10.1016/b978-0-12-494850-1.50022-0" @default.
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