FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899314255> ?p ?o ?g. }

• W2899314255 endingPage "e0206406" @default.
• W2899314255 startingPage "e0206406" @default.
• W2899314255 abstract "Background With increased access to antiretroviral treatment (ART) in sub-Saharan Africa emergence of HIV-1 pretreatment drug resistance constitutes a serious risk. This may lead to rapid virological failure in subjects initiating ART, and mother-to-child transmission despite prophylaxis. Methods Treatment-naïve pregnant women from four antenatal care clinics in Bissau, Guinea-Bissau, were enrolled from October 2016 to November 2017. Genotypic resistance testing and phylogenetic subtype analysis was performed on 48 specimens. Results Forty eight women met the survey inclusion criteria. All specimens were successfully amplified and genotyped. Specimens from five women were associated with HIV-1 drug resistance mutations. Four carried mutations exclusively linked to non-nucleoside reverse transcriptase inhibitors (NNRTIs) (K103N, K103N/S) and one carried mutations to both NNRTIs (G190S, K101E) and nucleoside reverse transcriptase inhibitors (NRTIs) (M184V). These results corresponded to 10.4% (95% CI: 4.5–22.2%), 2.1% (95% CI: 0.4–10.9%) and 0% (95% CI: 0.0–7.4%) drug resistance mutations to NNRTIs, NRTIs and protease inhibitors, respectively. HIV-1 circulating recombinant form 02AG was most commonly found, followed by HIV-1 sub-subtype A3. Subtype/CRF was not associated with drug resistance mutations. Conclusion Our study reports a 10.4% prevalence of pretreatment drug resistance to NNRTIs in HIV-1-infected pregnant women in the capital Bissau, Guinea Bissau. Since NNRTIs are part of first-line ART in the country, baseline resistance screenings or adjustment of national treatment guidelines should be considered as antiretroviral treatment programs are scaled up." @default.
• W2899314255 created "2018-11-09" @default.
• W2899314255 creator A5011323803 @default.
• W2899314255 creator A5028012123 @default.
• W2899314255 creator A5034084212 @default.
• W2899314255 creator A5036531520 @default.
• W2899314255 creator A5036718804 @default.
• W2899314255 creator A5043922179 @default.
• W2899314255 creator A5058627780 @default.
• W2899314255 creator A5086448571 @default.
• W2899314255 date "2018-10-31" @default.
• W2899314255 modified "2023-09-24" @default.
• W2899314255 title "Prevalence of HIV-1 pretreatment drug resistance among treatment naïve pregnant women in Bissau, Guinea Bissau" @default.
• W2899314255 cites W135664440 @default.
• W2899314255 cites W1904877136 @default.
• W2899314255 cites W1909386356 @default.
• W2899314255 cites W1971707621 @default.
• W2899314255 cites W1985640570 @default.
• W2899314255 cites W1998657923 @default.
• W2899314255 cites W2017776544 @default.
• W2899314255 cites W2025935798 @default.
• W2899314255 cites W2032771361 @default.
• W2899314255 cites W2044941368 @default.
• W2899314255 cites W2048253923 @default.
• W2899314255 cites W2065557732 @default.
• W2899314255 cites W2065970143 @default.
• W2899314255 cites W2068002734 @default.
• W2899314255 cites W2081539383 @default.
• W2899314255 cites W2082329556 @default.
• W2899314255 cites W2084625955 @default.
• W2899314255 cites W2089135598 @default.
• W2899314255 cites W2090564884 @default.
• W2899314255 cites W2093437302 @default.
• W2899314255 cites W2097123325 @default.
• W2899314255 cites W2101051323 @default.
• W2899314255 cites W2109046728 @default.
• W2899314255 cites W2111211467 @default.
• W2899314255 cites W2116049022 @default.
• W2899314255 cites W2119284380 @default.
• W2899314255 cites W2123613937 @default.
• W2899314255 cites W2139393856 @default.
• W2899314255 cites W2141008678 @default.
• W2899314255 cites W2143126277 @default.
• W2899314255 cites W2144280294 @default.
• W2899314255 cites W2146808131 @default.
• W2899314255 cites W2158986060 @default.
• W2899314255 cites W2170463669 @default.
• W2899314255 cites W2342485906 @default.
• W2899314255 cites W2462213043 @default.
• W2899314255 cites W2474685703 @default.
• W2899314255 cites W2542271008 @default.
• W2899314255 cites W2773364546 @default.
• W2899314255 cites W3011567179 @default.
• W2899314255 cites W65942279 @default.
• W2899314255 doi "https://doi.org/10.1371/journal.pone.0206406" @default.
• W2899314255 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6209301" @default.
• W2899314255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30379960" @default.
• W2899314255 hasPublicationYear "2018" @default.
• W2899314255 type Work @default.
• W2899314255 sameAs 2899314255 @default.
• W2899314255 citedByCount "11" @default.
• W2899314255 countsByYear W28993142552018 @default.
• W2899314255 countsByYear W28993142552019 @default.
• W2899314255 countsByYear W28993142552020 @default.
• W2899314255 countsByYear W28993142552021 @default.
• W2899314255 countsByYear W28993142552022 @default.
• W2899314255 countsByYear W28993142552023 @default.
• W2899314255 crossrefType "journal-article" @default.
• W2899314255 hasAuthorship W2899314255A5011323803 @default.
• W2899314255 hasAuthorship W2899314255A5028012123 @default.
• W2899314255 hasAuthorship W2899314255A5034084212 @default.
• W2899314255 hasAuthorship W2899314255A5036531520 @default.
• W2899314255 hasAuthorship W2899314255A5036718804 @default.
• W2899314255 hasAuthorship W2899314255A5043922179 @default.
• W2899314255 hasAuthorship W2899314255A5058627780 @default.
• W2899314255 hasAuthorship W2899314255A5086448571 @default.
• W2899314255 hasBestOaLocation W28993142551 @default.
• W2899314255 hasConcept C104317684 @default.
• W2899314255 hasConcept C114851261 @default.
• W2899314255 hasConcept C119599485 @default.
• W2899314255 hasConcept C126322002 @default.
• W2899314255 hasConcept C127413603 @default.
• W2899314255 hasConcept C135763542 @default.
• W2899314255 hasConcept C142462285 @default.
• W2899314255 hasConcept C156719811 @default.
• W2899314255 hasConcept C159047783 @default.
• W2899314255 hasConcept C182707283 @default.
• W2899314255 hasConcept C2777351918 @default.
• W2899314255 hasConcept C2778451633 @default.
• W2899314255 hasConcept C2779130552 @default.
• W2899314255 hasConcept C2781143361 @default.
• W2899314255 hasConcept C2993143319 @default.
• W2899314255 hasConcept C3013748606 @default.
• W2899314255 hasConcept C49105822 @default.
• W2899314255 hasConcept C54355233 @default.
• W2899314255 hasConcept C71924100 @default.
• W2899314255 hasConcept C761482 @default.
• W2899314255 hasConcept C86803240 @default.

• next