FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899315052> ?p ?o ?g. }

• W2899315052 endingPage "116" @default.
• W2899315052 startingPage "116" @default.
• W2899315052 abstract "Sodium-5,6-benzylidene-L-ascorbate (SBA), and its component units, benzaldehyde (BA) and sodium ascorbate (SA), are known to exert antitumor activity, while eugenol exerts anti-inflammatory activity. To narrow down their intracellular targets, metabolomic analysis was performed. Viable cell number was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. Fine cell structures were observed under transmission electron microscope. Cellular metabolites were extracted with methanol and subjected to capillary electrophoresis-mass spectrometry (CE-MS) for quantification of intracellular metabolites. Results showed that SBA was cleaved into BA and SA under acidic condition. Among these three compounds, BA showed the highest-tumor specificity in vitro against human oral squamous cell carcinoma (OSCC) cell line. BA did not induce the vacuolization in HSC-2 OSCC cells, and its cytotoxicity was not inhibited by catalase, in contrast to SBA and SA. Only BA suppressed the tricarboxylic acid (TCA) cycle at early stage of cytotoxicity induction. Eugenol more rapidly induced the vacuolization and suppressed the TCA cycle in three human normal oral cells (gingival fibroblast, periodontal ligament fibroblast, pulp cell). Neither BA nor eugenol affected the ATP utilization, further supporting that they do not induce apoptosis. The present study demonstrated for the first time that both BA and eugenol suppressed the TCA cycle in tumor cells and normal cells, respectively. It is crucial to design methodology that enhances the antitumor potential of BA and reduces the cytotoxicity of eugenol to allow for safe clinical application." @default.
• W2899315052 created "2018-11-09" @default.
• W2899315052 creator A5003433490 @default.
• W2899315052 creator A5014296768 @default.
• W2899315052 creator A5043528591 @default.
• W2899315052 creator A5043981307 @default.
• W2899315052 creator A5055052157 @default.
• W2899315052 creator A5065212781 @default.
• W2899315052 creator A5071767668 @default.
• W2899315052 date "2018-10-31" @default.
• W2899315052 modified "2023-10-04" @default.
• W2899315052 title "Changes in Metabolic Profiles of Human Oral Cells by Benzylidene Ascorbates and Eugenol" @default.
• W2899315052 cites W1157323190 @default.
• W2899315052 cites W115859731 @default.
• W2899315052 cites W118478495 @default.
• W2899315052 cites W135949251 @default.
• W2899315052 cites W1600102552 @default.
• W2899315052 cites W1793660252 @default.
• W2899315052 cites W1965758611 @default.
• W2899315052 cites W1969481911 @default.
• W2899315052 cites W1974897690 @default.
• W2899315052 cites W1984926446 @default.
• W2899315052 cites W1998277941 @default.
• W2899315052 cites W2007541799 @default.
• W2899315052 cites W2013223118 @default.
• W2899315052 cites W2018507034 @default.
• W2899315052 cites W2020676808 @default.
• W2899315052 cites W2026609725 @default.
• W2899315052 cites W2035147313 @default.
• W2899315052 cites W2049094525 @default.
• W2899315052 cites W2075451550 @default.
• W2899315052 cites W2096618924 @default.
• W2899315052 cites W2101698988 @default.
• W2899315052 cites W2121694020 @default.
• W2899315052 cites W2125085509 @default.
• W2899315052 cites W2149212516 @default.
• W2899315052 cites W2153964181 @default.
• W2899315052 cites W2170347547 @default.
• W2899315052 cites W2185248063 @default.
• W2899315052 cites W2196101497 @default.
• W2899315052 cites W2296547160 @default.
• W2899315052 cites W2396048773 @default.
• W2899315052 cites W2405041960 @default.
• W2899315052 cites W2409406640 @default.
• W2899315052 cites W2411509292 @default.
• W2899315052 cites W2429719136 @default.
• W2899315052 cites W2438453657 @default.
• W2899315052 cites W2590732849 @default.
• W2899315052 cites W2597922412 @default.
• W2899315052 cites W2990026427 @default.
• W2899315052 cites W3484683 @default.
• W2899315052 cites W35150446 @default.
• W2899315052 cites W4247038487 @default.
• W2899315052 cites W570798859 @default.
• W2899315052 cites W2186214594 @default.
• W2899315052 doi "https://doi.org/10.3390/medicines5040116" @default.
• W2899315052 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6313480" @default.
• W2899315052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30384403" @default.
• W2899315052 hasPublicationYear "2018" @default.
• W2899315052 type Work @default.
• W2899315052 sameAs 2899315052 @default.
• W2899315052 citedByCount "8" @default.
• W2899315052 countsByYear W28993150522019 @default.
• W2899315052 countsByYear W28993150522020 @default.
• W2899315052 countsByYear W28993150522021 @default.
• W2899315052 countsByYear W28993150522023 @default.
• W2899315052 crossrefType "journal-article" @default.
• W2899315052 hasAuthorship W2899315052A5003433490 @default.
• W2899315052 hasAuthorship W2899315052A5014296768 @default.
• W2899315052 hasAuthorship W2899315052A5043528591 @default.
• W2899315052 hasAuthorship W2899315052A5043981307 @default.
• W2899315052 hasAuthorship W2899315052A5055052157 @default.
• W2899315052 hasAuthorship W2899315052A5065212781 @default.
• W2899315052 hasAuthorship W2899315052A5071767668 @default.
• W2899315052 hasBestOaLocation W28993150521 @default.
• W2899315052 hasConcept C109316439 @default.
• W2899315052 hasConcept C134018914 @default.
• W2899315052 hasConcept C153911025 @default.
• W2899315052 hasConcept C178790620 @default.
• W2899315052 hasConcept C185592680 @default.
• W2899315052 hasConcept C190283241 @default.
• W2899315052 hasConcept C202751555 @default.
• W2899315052 hasConcept C2778614373 @default.
• W2899315052 hasConcept C2780381497 @default.
• W2899315052 hasConcept C2780470866 @default.
• W2899315052 hasConcept C54355233 @default.
• W2899315052 hasConcept C55493867 @default.
• W2899315052 hasConcept C79879829 @default.
• W2899315052 hasConcept C81885089 @default.
• W2899315052 hasConcept C86803240 @default.
• W2899315052 hasConceptScore W2899315052C109316439 @default.
• W2899315052 hasConceptScore W2899315052C134018914 @default.
• W2899315052 hasConceptScore W2899315052C153911025 @default.
• W2899315052 hasConceptScore W2899315052C178790620 @default.
• W2899315052 hasConceptScore W2899315052C185592680 @default.
• W2899315052 hasConceptScore W2899315052C190283241 @default.
• W2899315052 hasConceptScore W2899315052C202751555 @default.
• W2899315052 hasConceptScore W2899315052C2778614373 @default.

• next