FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899323218> ?p ?o ?g. }

• W2899323218 endingPage "75" @default.
• W2899323218 startingPage "62" @default.
• W2899323218 abstract "The canonical phosphodiesterase 4 (PDE4) inhibitors produce antidepressant-like effects in a variety of animal models. However, severe side effects, particularly vomiting and nausea, limit their clinical application. FCPR16 is a novel PDE4 inhibitor with less vomiting potential. However, whether it will exert an antidepressant-like effect remains unclear. Here, we aimed to evaluate the effect of FCPR16 in mice subjected to chronic unpredictable mild stress (CUMS). Our results showed that FCPR16 produced antidepressant-like effects in multiple behavioral tests, including a forced swimming test, tail suspension test, sucrose preference test and novelty suppression feeding test. Simultaneously, data indicated that FCPR16 enhanced the levels of several proteins, including cAMP, brain derived neurotrophic factor, exchange protein directly activated by cAMP 2 (EPAC-2), synapsin1, postsynaptic density protein 95, phosphorylated cAMP response element binding protein and extracellular regulated protein kinases 1/2, which were downregulated by CUMS in both the cerebral cortex and hippocampus. The number of DCX+ cells in the hippocampus of CUMS mice was increased after FCPR16 treatment. Moreover, treatment with FCPR16 resulted in decreased expression of pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) and increased expression of anti-inflammatory cytokines (IL-10) in mice challenged with CUMS. Consistently, the mRNA levels of microglial M1 markers (iNOS and TNF-α) were downregulated, while M2 markers (Arginase 1 and CD206) were upregulated in CUMS-exposed mice after FCPR16 treatment. Immunofluorescence analysis showed that FCPR16 inhibited the activation of microglial cells and increased the number of CD206+ in CUMS-exposed mice. Collectively, these results suggested that FCPR16 is a potential compound with effects against depressive-like behaviors, and the antidepressant-like effect of FCPR16 is possibly mediated through activation of the cAMP-mediated signaling pathways and inhibition of neuroinflammation in both the cerebral cortex and hippocampus." @default.
• W2899323218 created "2018-11-09" @default.
• W2899323218 creator A5005486813 @default.
• W2899323218 creator A5033237183 @default.
• W2899323218 creator A5045366618 @default.
• W2899323218 creator A5073498310 @default.
• W2899323218 creator A5074238421 @default.
• W2899323218 creator A5087276315 @default.
• W2899323218 creator A5091584403 @default.
• W2899323218 date "2019-03-01" @default.
• W2899323218 modified "2023-10-14" @default.
• W2899323218 title "FCPR16, a novel phosphodiesterase 4 inhibitor, produces an antidepressant-like effect in mice exposed to chronic unpredictable mild stress" @default.
• W2899323218 cites W1496381585 @default.
• W2899323218 cites W1565490432 @default.
• W2899323218 cites W1913344680 @default.
• W2899323218 cites W1976624715 @default.
• W2899323218 cites W1977430165 @default.
• W2899323218 cites W1979407816 @default.
• W2899323218 cites W1980108852 @default.
• W2899323218 cites W1981476436 @default.
• W2899323218 cites W1986611577 @default.
• W2899323218 cites W1993548704 @default.
• W2899323218 cites W2000232109 @default.
• W2899323218 cites W2021482385 @default.
• W2899323218 cites W2022870580 @default.
• W2899323218 cites W2030727754 @default.
• W2899323218 cites W2034630933 @default.
• W2899323218 cites W2050836998 @default.
• W2899323218 cites W2052012904 @default.
• W2899323218 cites W2062717336 @default.
• W2899323218 cites W2065622820 @default.
• W2899323218 cites W2067535960 @default.
• W2899323218 cites W2074349137 @default.
• W2899323218 cites W2075255987 @default.
• W2899323218 cites W2078037416 @default.
• W2899323218 cites W2081046173 @default.
• W2899323218 cites W2083351038 @default.
• W2899323218 cites W2086615652 @default.
• W2899323218 cites W2089417699 @default.
• W2899323218 cites W2096951505 @default.
• W2899323218 cites W2104479866 @default.
• W2899323218 cites W2104516271 @default.
• W2899323218 cites W2106623141 @default.
• W2899323218 cites W2120234117 @default.
• W2899323218 cites W2122384242 @default.
• W2899323218 cites W2124073673 @default.
• W2899323218 cites W2137216702 @default.
• W2899323218 cites W2148137246 @default.
• W2899323218 cites W2151935175 @default.
• W2899323218 cites W2156150528 @default.
• W2899323218 cites W2156624679 @default.
• W2899323218 cites W2167193785 @default.
• W2899323218 cites W2324745882 @default.
• W2899323218 cites W2343854002 @default.
• W2899323218 cites W2346390990 @default.
• W2899323218 cites W2491400549 @default.
• W2899323218 cites W2509108559 @default.
• W2899323218 cites W2517405161 @default.
• W2899323218 cites W2529847745 @default.
• W2899323218 cites W2580816993 @default.
• W2899323218 cites W2591693802 @default.
• W2899323218 cites W2594777970 @default.
• W2899323218 cites W2604652480 @default.
• W2899323218 cites W2608614727 @default.
• W2899323218 cites W2737842237 @default.
• W2899323218 cites W2768222149 @default.
• W2899323218 cites W2769533802 @default.
• W2899323218 cites W2775415478 @default.
• W2899323218 cites W2789439351 @default.
• W2899323218 cites W2791148478 @default.
• W2899323218 cites W2796364626 @default.
• W2899323218 cites W3022052974 @default.
• W2899323218 cites W4200581136 @default.
• W2899323218 doi "https://doi.org/10.1016/j.pnpbp.2018.10.017" @default.
• W2899323218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30391306" @default.
• W2899323218 hasPublicationYear "2019" @default.
• W2899323218 type Work @default.
• W2899323218 sameAs 2899323218 @default.
• W2899323218 citedByCount "21" @default.
• W2899323218 countsByYear W28993232182019 @default.
• W2899323218 countsByYear W28993232182020 @default.
• W2899323218 countsByYear W28993232182021 @default.
• W2899323218 countsByYear W28993232182022 @default.
• W2899323218 countsByYear W28993232182023 @default.
• W2899323218 crossrefType "journal-article" @default.
• W2899323218 hasAuthorship W2899323218A5005486813 @default.
• W2899323218 hasAuthorship W2899323218A5033237183 @default.
• W2899323218 hasAuthorship W2899323218A5045366618 @default.
• W2899323218 hasAuthorship W2899323218A5073498310 @default.
• W2899323218 hasAuthorship W2899323218A5074238421 @default.
• W2899323218 hasAuthorship W2899323218A5087276315 @default.
• W2899323218 hasAuthorship W2899323218A5091584403 @default.
• W2899323218 hasConcept C104317684 @default.
• W2899323218 hasConcept C126322002 @default.
• W2899323218 hasConcept C127561419 @default.
• W2899323218 hasConcept C134018914 @default.
• W2899323218 hasConcept C136569192 @default.
• W2899323218 hasConcept C160539049 @default.

• next