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• W2899324048 abstract "It is believed that the main factors determining the prognosis for cancer are the prevalence and degree of differentiation of the tumor. In recent years, more and more attention has been paid to genetic factors that determine the individual risk of developing cancer, and also participate in the processes of carcinogenesis in general. Therefore, the study of molecular-biological tumor markers, which are specific indicators of the high risk of tumor progression and the relationship to treatment efficacy, has acquired clinical significance. Objective. To study the effectiveness of treatment of patients with osteosarcoma depending on the change in expression of the p53 gene. Materials and methods. Under supervision were 221 patients with osteosarcoma. Patients received various types of treatment. Neoadjuvant polychemotherapy (PCT) was performed in 184 (83.2%) patients, of which 131 (71.2%) patients underwent systemic neoadjuvant CT, and 29 (15.7%) patients underwent prolonged intraarterial regional chemotherapy (PIRC). A combination of systemic PCT and PIRC was performed by 24 (13.0%) patients. IHC was performed by avidin-biotin-peroxidase using a standard procedure using primary antibodies (Dako, Novocastra ™) to mp53. Results. Analysis of the obtained data made it possible to establish that expression and overexpression of mtp 53+ occurs in patients with osteosarcoma with a low degree of tumor differentiation (G3) 9 times more often. In patients with stage 3 and 4 clinical stages of osteosarcoma, the positive response of mtp 53+ was 4-fold higher compared to patients with 1-2 stages. Achievement of complete morphological regression during IHC was revealed in 13% of patients, among them in 70.6% of patients the expression of mutant p53 gene was absent. At 15.7% after the use of the PIRC scheme, complete morphological regression was observed, in 87.5% of these patients the mutant p53 gene was also absent. The conclusion. High and average expression of the mutant p53 gene in patients with OS has an associative association with a low degree of tumor differentiation (G3), with stages 3 and 4 of the tumor process, with a large tumor size, low pathomorphism (1 and 2), with a chondroblastic histological variant and osteolytic radiological form. The decrease in the timing of relapses, distant metastases and life expectancy in patients with mild and high expression of the mtp53 gene was found, regardless of the therapy." @default.
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• W2899324048 date "2018-01-01" @default.
• W2899324048 modified "2023-09-27" @default.
• W2899324048 title "The Prognostic Value of Mutant Gene P53 in Patients with Osteosarcoma" @default.
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