FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899337360> ?p ?o ?g. }

• W2899337360 endingPage "11867" @default.
• W2899337360 startingPage "11865" @default.
• W2899337360 abstract "There is a growing appreciation that macrophages contribute to innate immune memory against microbial pathogens in ways that are distinct from and complementary to adaptive immune memory. In PNAS, Chan et al. (1) report that macrophages develop memory against Staphylococcus aureus skin and skin structure infections (SSSIs) and that this memory is tissue specific and can be transferred between individual animals.Immune memory against S. aureus is important because of the immense impact of this microbe on human health and because effective immunity against recurrent S. aureus infections can be difficult to achieve. S. aureus is the most common cause of skin infections (2). These are often associated with massive morbidity, mortality, and health care expenditures (3). Patients often experience high rates of recurrence (4), suggesting that some individuals have difficulty with establishing protective immunity against this organism. Humoral immunity in particular can often be ineffective because antibodies directed against S. aureus virulence factors may not be sufficient for protection (5). Consistent with this, individuals with impaired humoral immunity are not necessarily at increased risk for S. aureus infections (6), and an effective vaccine against S. aureus has thus far proved elusive (7). Memory T cell responses, while robust, can likewise be ineffectual (8). These data suggest that adaptive immunity alone is unlikely to provide effective protection against S. aureus infection.Studies of individuals with recurrent S. aureus infections in the context of a primary immunodeficiency have revealed critical roles for select cell types and immune mechanisms in protection against this potential pathogen. These include defects in IL-17 production associated with hyper-IgE syndrome (Job’s disease) (9). IL-17 was likewise shown in mouse models of S. aureus infection to be critical for neutrophil recruitment, abscess formation, and bacterial clearance (10 … [↵][1]1To whom correspondence should be addressed. Email: pbollyky{at}stanford.edu. [1]: #xref-corresp-1-1" @default.
• W2899337360 created "2018-11-09" @default.
• W2899337360 creator A5044292652 @default.
• W2899337360 creator A5062852401 @default.
• W2899337360 date "2018-11-02" @default.
• W2899337360 modified "2023-10-18" @default.
• W2899337360 title "Macrophages and innate immune memory against <i>Staphylococcus</i> skin infections" @default.
• W2899337360 cites W1979106767 @default.
• W2899337360 cites W1999481547 @default.
• W2899337360 cites W2005294321 @default.
• W2899337360 cites W2016850513 @default.
• W2899337360 cites W2029665048 @default.
• W2899337360 cites W2084801194 @default.
• W2899337360 cites W2101012179 @default.
• W2899337360 cites W2103675658 @default.
• W2899337360 cites W2111157195 @default.
• W2899337360 cites W2114002456 @default.
• W2899337360 cites W2116797415 @default.
• W2899337360 cites W2137176031 @default.
• W2899337360 cites W2158070898 @default.
• W2899337360 cites W2168836899 @default.
• W2899337360 cites W2402278867 @default.
• W2899337360 cites W2549994717 @default.
• W2899337360 cites W2897273246 @default.
• W2899337360 doi "https://doi.org/10.1073/pnas.1816935115" @default.
• W2899337360 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6255183" @default.
• W2899337360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30389708" @default.
• W2899337360 hasPublicationYear "2018" @default.
• W2899337360 type Work @default.
• W2899337360 sameAs 2899337360 @default.
• W2899337360 citedByCount "10" @default.
• W2899337360 countsByYear W28993373602021 @default.
• W2899337360 countsByYear W28993373602022 @default.
• W2899337360 countsByYear W28993373602023 @default.
• W2899337360 crossrefType "journal-article" @default.
• W2899337360 hasAuthorship W2899337360A5044292652 @default.
• W2899337360 hasAuthorship W2899337360A5062852401 @default.
• W2899337360 hasBestOaLocation W28993373601 @default.
• W2899337360 hasConcept C136449434 @default.
• W2899337360 hasConcept C203014093 @default.
• W2899337360 hasConcept C2779288629 @default.
• W2899337360 hasConcept C2779341262 @default.
• W2899337360 hasConcept C2779489039 @default.
• W2899337360 hasConcept C2991763054 @default.
• W2899337360 hasConcept C523546767 @default.
• W2899337360 hasConcept C54355233 @default.
• W2899337360 hasConcept C86803240 @default.
• W2899337360 hasConcept C8891405 @default.
• W2899337360 hasConcept C89423630 @default.
• W2899337360 hasConceptScore W2899337360C136449434 @default.
• W2899337360 hasConceptScore W2899337360C203014093 @default.
• W2899337360 hasConceptScore W2899337360C2779288629 @default.
• W2899337360 hasConceptScore W2899337360C2779341262 @default.
• W2899337360 hasConceptScore W2899337360C2779489039 @default.
• W2899337360 hasConceptScore W2899337360C2991763054 @default.
• W2899337360 hasConceptScore W2899337360C523546767 @default.
• W2899337360 hasConceptScore W2899337360C54355233 @default.
• W2899337360 hasConceptScore W2899337360C86803240 @default.
• W2899337360 hasConceptScore W2899337360C8891405 @default.
• W2899337360 hasConceptScore W2899337360C89423630 @default.
• W2899337360 hasFunder F4320310642 @default.
• W2899337360 hasFunder F4320337355 @default.
• W2899337360 hasIssue "47" @default.
• W2899337360 hasLocation W28993373601 @default.
• W2899337360 hasLocation W28993373602 @default.
• W2899337360 hasLocation W28993373603 @default.
• W2899337360 hasLocation W28993373604 @default.
• W2899337360 hasOpenAccess W2899337360 @default.
• W2899337360 hasPrimaryLocation W28993373601 @default.
• W2899337360 hasRelatedWork W1921288393 @default.
• W2899337360 hasRelatedWork W2006838528 @default.
• W2899337360 hasRelatedWork W2141330728 @default.
• W2899337360 hasRelatedWork W2188294308 @default.
• W2899337360 hasRelatedWork W2288992930 @default.
• W2899337360 hasRelatedWork W2792398028 @default.
• W2899337360 hasRelatedWork W3209390153 @default.
• W2899337360 hasRelatedWork W4249816251 @default.
• W2899337360 hasRelatedWork W4317391941 @default.
• W2899337360 hasRelatedWork W4375865726 @default.
• W2899337360 hasVolume "115" @default.
• W2899337360 isParatext "false" @default.
• W2899337360 isRetracted "false" @default.
• W2899337360 magId "2899337360" @default.
• W2899337360 workType "article" @default.