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- W2899337597 endingPage "1123" @default.
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- W2899337597 abstract "The endolysosomal, non-selective cation channels, two-pore channels (TPCs) and mucolipins (TRPMLs), regulate intracellular membrane dynamics and autophagy. While partially compensatory for each other, isoform-specific intracellular distribution, cell-type expression patterns, and regulatory mechanisms suggest different channel isoforms confer distinct properties to the cell. Briefly, established TPC/TRPML functions and interaction partners (‘interactomes’) are discussed. Novel TRPML3 interactors are shown, and a meta-analysis of experimentally obtained channel interactomes conducted. Accordingly, interactomes are compared and contrasted, and subsequently described in detail for TPC1, TPC2, TRPML1, and TRPML3. TPC interactomes are well-defined, encompassing intracellular membrane organisation proteins. TRPML interactomes are varied, encompassing cardiac contractility- and chaperone-mediated autophagy proteins, alongside regulators of intercellular signalling. Comprising recently proposed targets to treat cancers, infections, metabolic disease and neurodegeneration, the advancement of TPC/TRPML understanding is of considerable importance. This review proposes novel directions elucidating TPC/TRPML relevance in health and disease. This article is part of a Special Issue entitled: ECS Meeting edited by Claus Heizmann, Joachim Krebs and Jacques Haiech." @default.
- W2899337597 created "2018-11-09" @default.
- W2899337597 creator A5010133727 @default.
- W2899337597 creator A5018377011 @default.
- W2899337597 creator A5075508364 @default.
- W2899337597 creator A5089190614 @default.
- W2899337597 date "2019-07-01" @default.
- W2899337597 modified "2023-09-26" @default.
- W2899337597 title "The protein interaction networks of mucolipins and two-pore channels" @default.
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