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• W2899343961 abstract "// Kirsty R. Greenow 1 , Matthew Zverev 1 , Stephanie May 1 , Howard Kendrick 1 , Geraint T. Williams 2 , Toby Phesse 1 and Lee Parry 1 1 European Cancer Stem Cell Research Institute, Cardiff School of Biosciences, Cardiff University, Cardiff, UK 2 School of Medicine, Cardiff University, Cardiff, UK Correspondence to: Lee Parry, email: parryl3@cardiff.ac.uk Keywords: Lect2; Wnt; colorectal cancer; inflammation; intestine Received: December 04, 2017      Accepted: October 28, 2018      Published: November 23, 2018 ABSTRACT Leukocyte cell-derived chemotaxin 2 (Lect2) is a chemokine-like chemotactic factor that has been identified as a downstream target of the Wnt signalling pathway. Whilst the primary function of Lect2 is thought to be in modulating the inflammatory process, it has recently been implicated as a potential inhibitor of the Wnt pathway. Deregulation of the Wnt pathway, often due to loss of the negative regulator APC , is found in ~80% of colorectal cancer (CRC). Here we have used the Apc Min/+ Lect2 −/− mouse model to characterise the role of Lect2 in Wnt-driven intestinal tumourigenesis. Histopathological, immunohistochemical, PCR and flow cytometry analysis were employed to identify the role of Lect2 in the intestine. The Apc Min/+ Lect2 −/− mice had a reduced mean survival and a significantly increased number of adenomas in the small intestine with increased severity. Analysis of Lect2 loss indicated it had no effect on the Wnt pathway in the intestine but significant differences were observed in circulating inflammatory markers, CD4+ T cells, and T cell lineage-specification factors. In summary, in the murine intestine loss of Lect2 promotes the initiation and progression of Wnt-driven colorectal cancer. This protection is performed independently of the Wnt signalling pathway and is associated with an altered inflammatory environment during Wnt-driven tumorigenesis." @default.
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• W2899343961 date "2018-11-23" @default.
• W2899343961 modified "2023-10-01" @default.
• W2899343961 title "<i>Lect2</i> deficiency is characterised by altered cytokine levels and promotion of intestinal tumourigenesis" @default.
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• W2899343961 doi "https://doi.org/10.18632/oncotarget.26335" @default.
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