Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899344524> ?p ?o ?g. }
- W2899344524 endingPage "4848" @default.
- W2899344524 startingPage "4834" @default.
- W2899344524 abstract "Numerous mitochondrial quality control mechanisms exist within cells, but none have been shown to effectively assess and control the quality of mitochondrial DNA (mtDNA). One reason such mechanisms have yet to be elucidated is that they do not appear to be particularly active in most somatic cells, where many studies are conducted. The female germline, the cell lineage that gives rise to eggs, appears to be an exception. In the germline, strong purifying selection pathways act to eliminate deleterious mtDNA. These pathways have apparently evolved to prevent pathogenic mtDNA mutations from accumulating over successive generations and causing a decline of species via Muller's ratchet. Despite their fundamental biological importance, the mechanisms underlying purifying selection remain poorly understood, with no genes involved in this process yet identified. In this review, we discuss recent studies exploring mechanisms of germline mtDNA purifying selection in both mammalian and invertebrate systems. We also discuss the challenges to future major advances. Understanding the molecular basis of purifying selection is not only a fundamental outstanding question in biology, but may also pave the way to controlling selection in somatic tissues, potentially leading to treatments for people suffering from mitochondrial diseases." @default.
- W2899344524 created "2018-11-09" @default.
- W2899344524 creator A5020828313 @default.
- W2899344524 creator A5066181905 @default.
- W2899344524 creator A5080371857 @default.
- W2899344524 date "2018-12-01" @default.
- W2899344524 modified "2023-10-17" @default.
- W2899344524 title "Mitochondrial DNA Purifying Selection in Mammals and Invertebrates" @default.
- W2899344524 cites W1518704304 @default.
- W2899344524 cites W1521947818 @default.
- W2899344524 cites W1553962779 @default.
- W2899344524 cites W1561497451 @default.
- W2899344524 cites W1621005218 @default.
- W2899344524 cites W1703028909 @default.
- W2899344524 cites W1811556804 @default.
- W2899344524 cites W1829371983 @default.
- W2899344524 cites W1848815581 @default.
- W2899344524 cites W1876544915 @default.
- W2899344524 cites W1926293196 @default.
- W2899344524 cites W1964126982 @default.
- W2899344524 cites W1966461639 @default.
- W2899344524 cites W1967109689 @default.
- W2899344524 cites W1968192113 @default.
- W2899344524 cites W1970176101 @default.
- W2899344524 cites W1971564824 @default.
- W2899344524 cites W1977545536 @default.
- W2899344524 cites W1979429330 @default.
- W2899344524 cites W1981161568 @default.
- W2899344524 cites W1983724570 @default.
- W2899344524 cites W1984074065 @default.
- W2899344524 cites W1985469310 @default.
- W2899344524 cites W1987954830 @default.
- W2899344524 cites W1988344228 @default.
- W2899344524 cites W1988643971 @default.
- W2899344524 cites W1992224295 @default.
- W2899344524 cites W1992477424 @default.
- W2899344524 cites W1993594952 @default.
- W2899344524 cites W1994003350 @default.
- W2899344524 cites W1996097229 @default.
- W2899344524 cites W1996813968 @default.
- W2899344524 cites W1996943057 @default.
- W2899344524 cites W1997360166 @default.
- W2899344524 cites W1998352164 @default.
- W2899344524 cites W1998955483 @default.
- W2899344524 cites W1999223830 @default.
- W2899344524 cites W2000454435 @default.
- W2899344524 cites W2003672519 @default.
- W2899344524 cites W2005520835 @default.
- W2899344524 cites W2006662323 @default.
- W2899344524 cites W2006876928 @default.
- W2899344524 cites W2007003847 @default.
- W2899344524 cites W2009053617 @default.
- W2899344524 cites W2010675523 @default.
- W2899344524 cites W2011116207 @default.
- W2899344524 cites W2012998724 @default.
- W2899344524 cites W2013588487 @default.
- W2899344524 cites W2014401528 @default.
- W2899344524 cites W2015897815 @default.
- W2899344524 cites W2016241188 @default.
- W2899344524 cites W2017010329 @default.
- W2899344524 cites W2017363253 @default.
- W2899344524 cites W2018683367 @default.
- W2899344524 cites W2019219052 @default.
- W2899344524 cites W2020127384 @default.
- W2899344524 cites W2022312470 @default.
- W2899344524 cites W2026197201 @default.
- W2899344524 cites W2028174481 @default.
- W2899344524 cites W2028335500 @default.
- W2899344524 cites W2030656510 @default.
- W2899344524 cites W2032181723 @default.
- W2899344524 cites W2036988144 @default.
- W2899344524 cites W2040151712 @default.
- W2899344524 cites W2043396979 @default.
- W2899344524 cites W2043696089 @default.
- W2899344524 cites W2044221417 @default.
- W2899344524 cites W2044283072 @default.
- W2899344524 cites W2044897807 @default.
- W2899344524 cites W2045716211 @default.
- W2899344524 cites W2050395183 @default.
- W2899344524 cites W2054478802 @default.
- W2899344524 cites W2060153293 @default.
- W2899344524 cites W2061237546 @default.
- W2899344524 cites W2062920562 @default.
- W2899344524 cites W2063093762 @default.
- W2899344524 cites W2063794077 @default.
- W2899344524 cites W2067091330 @default.
- W2899344524 cites W2070392246 @default.
- W2899344524 cites W2071040218 @default.
- W2899344524 cites W2075132799 @default.
- W2899344524 cites W2079092251 @default.
- W2899344524 cites W2080844913 @default.
- W2899344524 cites W2082103906 @default.
- W2899344524 cites W2086399579 @default.
- W2899344524 cites W2088143914 @default.
- W2899344524 cites W2088995367 @default.
- W2899344524 cites W2091385966 @default.
- W2899344524 cites W2091909910 @default.
- W2899344524 cites W2094832206 @default.