Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899346318> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2899346318 abstract "This paper employs a computational model to study the dual gating modalities of BK channels in smooth muscles. These channels are gated by both membrane potential and intracellular calcium concentration. It has been previously reported that the sensors for these two stimuli are located at different regions of the channel. Thus, the two sensing modalities act independent of each other. Yet, they result in a concerted and synergistic opening of the channel pore. In this paper, we investigate the effects of these two gating mechanisms by computing the effective gating charges contributed by the channel's voltage and calcium sensors. Along with their independent contributions, we study and estimate the interplay and effect of these two modalities on the channel's activation. The voltage and calcium sensors appear to share the 'load' of the gating charges required to activate the channel based on the cytosolic calcium concentration and membrane potential. Thus, through our computational model, we demonstrate how the two independent sensors gate and coordinate the activation of the channel." @default.
- W2899346318 created "2018-11-09" @default.
- W2899346318 creator A5058762205 @default.
- W2899346318 date "2018-07-01" @default.
- W2899346318 modified "2023-09-27" @default.
- W2899346318 title "Effect of Gating Charges on Mediating the Dual Activation of BK Channels in Smooth Muscle Cells: A Computational Study" @default.
- W2899346318 cites W2033080277 @default.
- W2899346318 cites W2061197019 @default.
- W2899346318 cites W2063479136 @default.
- W2899346318 cites W2067967075 @default.
- W2899346318 cites W2076747420 @default.
- W2899346318 cites W2093090047 @default.
- W2899346318 cites W2094950759 @default.
- W2899346318 cites W2131653108 @default.
- W2899346318 cites W2166084555 @default.
- W2899346318 cites W2760315922 @default.
- W2899346318 doi "https://doi.org/10.1109/embc.2018.8513579" @default.
- W2899346318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30441663" @default.
- W2899346318 hasPublicationYear "2018" @default.
- W2899346318 type Work @default.
- W2899346318 sameAs 2899346318 @default.
- W2899346318 citedByCount "1" @default.
- W2899346318 countsByYear W28993463182019 @default.
- W2899346318 crossrefType "proceedings-article" @default.
- W2899346318 hasAuthorship W2899346318A5058762205 @default.
- W2899346318 hasConcept C12554922 @default.
- W2899346318 hasConcept C127162648 @default.
- W2899346318 hasConcept C178790620 @default.
- W2899346318 hasConcept C181911157 @default.
- W2899346318 hasConcept C185592680 @default.
- W2899346318 hasConcept C18699975 @default.
- W2899346318 hasConcept C194544171 @default.
- W2899346318 hasConcept C41008148 @default.
- W2899346318 hasConcept C519063684 @default.
- W2899346318 hasConcept C61144316 @default.
- W2899346318 hasConcept C76155785 @default.
- W2899346318 hasConcept C85520022 @default.
- W2899346318 hasConcept C86803240 @default.
- W2899346318 hasConceptScore W2899346318C12554922 @default.
- W2899346318 hasConceptScore W2899346318C127162648 @default.
- W2899346318 hasConceptScore W2899346318C178790620 @default.
- W2899346318 hasConceptScore W2899346318C181911157 @default.
- W2899346318 hasConceptScore W2899346318C185592680 @default.
- W2899346318 hasConceptScore W2899346318C18699975 @default.
- W2899346318 hasConceptScore W2899346318C194544171 @default.
- W2899346318 hasConceptScore W2899346318C41008148 @default.
- W2899346318 hasConceptScore W2899346318C519063684 @default.
- W2899346318 hasConceptScore W2899346318C61144316 @default.
- W2899346318 hasConceptScore W2899346318C76155785 @default.
- W2899346318 hasConceptScore W2899346318C85520022 @default.
- W2899346318 hasConceptScore W2899346318C86803240 @default.
- W2899346318 hasLocation W28993463181 @default.
- W2899346318 hasLocation W28993463182 @default.
- W2899346318 hasOpenAccess W2899346318 @default.
- W2899346318 hasPrimaryLocation W28993463181 @default.
- W2899346318 hasRelatedWork W1574962719 @default.
- W2899346318 hasRelatedWork W1983913756 @default.
- W2899346318 hasRelatedWork W1997884758 @default.
- W2899346318 hasRelatedWork W2000598241 @default.
- W2899346318 hasRelatedWork W2002540382 @default.
- W2899346318 hasRelatedWork W2046271917 @default.
- W2899346318 hasRelatedWork W2048240919 @default.
- W2899346318 hasRelatedWork W2110188816 @default.
- W2899346318 hasRelatedWork W2125720379 @default.
- W2899346318 hasRelatedWork W3013130643 @default.
- W2899346318 isParatext "false" @default.
- W2899346318 isRetracted "false" @default.
- W2899346318 magId "2899346318" @default.
- W2899346318 workType "article" @default.