FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899347146> ?p ?o ?g. }

• W2899347146 abstract "Summary FOXO transcription factors have long been associated with longevity control and tissue homeostasis. Although the transcriptional regulation of FOXO have been previously characterized (especially in long-lived insulin mutants and under stress conditions), how normal aging impacts the transcriptional activity of FOXO is poorly understood. Here, we conducted a chromatin immunoprecipitation sequencing (ChIP-Seq) analysis in both young and old wild-type fruit flies, Drosophila melanogaster , to evaluate the dynamics of FOXO gene targeting during aging. Intriguingly, the number of FOXO-bound genes dramatically decreases with age (from 2617 to 224). Consistent to the reduction of FOXO binding activity, many genes targeted by FOXO in young flies are transcriptionally altered with age, either up-regulated (FOXO-repressing genes) or down-regulated (FOXO-activating genes). In addition, we show that many FOXO-bound genes in wild-type flies are unique from those in insulin receptor substrate chico mutants. Distinct from chico mutants, FOXO targets specific cellular processes (e.g., actin cytoskeleton) and signaling pathways (e.g., Hippo, MAPK) in young wild-type flies. FOXO targeting on these pathways decreases with age. Interestingly, FOXO targets in old flies are enriched in cellular processes like chromatin organization and nucleosome assembly. Furthermore, FOXO binding to core histone genes is well maintained at aged flies. Together, our findings provide new insights into dynamic FOXO targeting under normal aging and highlight the diverse and understudied regulatory mechanisms for FOXO transcriptional activity." @default.
• W2899347146 created "2018-11-09" @default.
• W2899347146 creator A5030967805 @default.
• W2899347146 creator A5038419250 @default.
• W2899347146 creator A5048198050 @default.
• W2899347146 creator A5065691097 @default.
• W2899347146 creator A5087249396 @default.
• W2899347146 date "2018-10-30" @default.
• W2899347146 modified "2023-10-03" @default.
• W2899347146 title "Age-dependent changes in transcription factor FOXO targeting in Drosophila melanogaster" @default.
• W2899347146 cites W1508829110 @default.
• W2899347146 cites W1586705837 @default.
• W2899347146 cites W1593127829 @default.
• W2899347146 cites W1972597570 @default.
• W2899347146 cites W1976050844 @default.
• W2899347146 cites W1985234259 @default.
• W2899347146 cites W1985425785 @default.
• W2899347146 cites W1987648149 @default.
• W2899347146 cites W1990955843 @default.
• W2899347146 cites W1992800757 @default.
• W2899347146 cites W2001604240 @default.
• W2899347146 cites W2012178564 @default.
• W2899347146 cites W2021766527 @default.
• W2899347146 cites W2025457067 @default.
• W2899347146 cites W2030484015 @default.
• W2899347146 cites W2033440293 @default.
• W2899347146 cites W2035926347 @default.
• W2899347146 cites W2044144433 @default.
• W2899347146 cites W2046989794 @default.
• W2899347146 cites W2049009766 @default.
• W2899347146 cites W2053456833 @default.
• W2899347146 cites W2077157725 @default.
• W2899347146 cites W2078291208 @default.
• W2899347146 cites W2082852887 @default.
• W2899347146 cites W2083516240 @default.
• W2899347146 cites W2084796956 @default.
• W2899347146 cites W2088170258 @default.
• W2899347146 cites W2092985705 @default.
• W2899347146 cites W2099364141 @default.
• W2899347146 cites W2126525177 @default.
• W2899347146 cites W2130095246 @default.
• W2899347146 cites W2131255154 @default.
• W2899347146 cites W2131707839 @default.
• W2899347146 cites W2137035181 @default.
• W2899347146 cites W2143810570 @default.
• W2899347146 cites W2145084130 @default.
• W2899347146 cites W2162434225 @default.
• W2899347146 cites W2162857699 @default.
• W2899347146 cites W2166525118 @default.
• W2899347146 cites W2171124011 @default.
• W2899347146 cites W2192708678 @default.
• W2899347146 cites W2255416290 @default.
• W2899347146 cites W2331547930 @default.
• W2899347146 cites W2806379121 @default.
• W2899347146 cites W4240809199 @default.
• W2899347146 doi "https://doi.org/10.1101/456426" @default.
• W2899347146 hasPublicationYear "2018" @default.
• W2899347146 type Work @default.
• W2899347146 sameAs 2899347146 @default.
• W2899347146 citedByCount "1" @default.
• W2899347146 countsByYear W28993471462019 @default.
• W2899347146 crossrefType "posted-content" @default.
• W2899347146 hasAuthorship W2899347146A5030967805 @default.
• W2899347146 hasAuthorship W2899347146A5038419250 @default.
• W2899347146 hasAuthorship W2899347146A5048198050 @default.
• W2899347146 hasAuthorship W2899347146A5065691097 @default.
• W2899347146 hasAuthorship W2899347146A5087249396 @default.
• W2899347146 hasBestOaLocation W28993471461 @default.
• W2899347146 hasConcept C101762097 @default.
• W2899347146 hasConcept C104317684 @default.
• W2899347146 hasConcept C134320426 @default.
• W2899347146 hasConcept C143065580 @default.
• W2899347146 hasConcept C150194340 @default.
• W2899347146 hasConcept C2780104201 @default.
• W2899347146 hasConcept C2908554999 @default.
• W2899347146 hasConcept C54355233 @default.
• W2899347146 hasConcept C83640560 @default.
• W2899347146 hasConcept C86339819 @default.
• W2899347146 hasConcept C86803240 @default.
• W2899347146 hasConcept C95444343 @default.
• W2899347146 hasConceptScore W2899347146C101762097 @default.
• W2899347146 hasConceptScore W2899347146C104317684 @default.
• W2899347146 hasConceptScore W2899347146C134320426 @default.
• W2899347146 hasConceptScore W2899347146C143065580 @default.
• W2899347146 hasConceptScore W2899347146C150194340 @default.
• W2899347146 hasConceptScore W2899347146C2780104201 @default.
• W2899347146 hasConceptScore W2899347146C2908554999 @default.
• W2899347146 hasConceptScore W2899347146C54355233 @default.
• W2899347146 hasConceptScore W2899347146C83640560 @default.
• W2899347146 hasConceptScore W2899347146C86339819 @default.
• W2899347146 hasConceptScore W2899347146C86803240 @default.
• W2899347146 hasConceptScore W2899347146C95444343 @default.
• W2899347146 hasLocation W28993471461 @default.
• W2899347146 hasOpenAccess W2899347146 @default.
• W2899347146 hasPrimaryLocation W28993471461 @default.
• W2899347146 hasRelatedWork W1969421403 @default.
• W2899347146 hasRelatedWork W2002532134 @default.
• W2899347146 hasRelatedWork W2021959806 @default.
• W2899347146 hasRelatedWork W2111958127 @default.
• W2899347146 hasRelatedWork W2150914257 @default.

• next