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• W2899350018 abstract "Heparin is a polysaccharide anticoagulant drug isolated from animal tissues. There have been concerns on the safety and security of the heparin supply chain since 2007-8 when a contamination crisis led to its disruption. The current study applies a suite of modern analytical techniques to porcine, bovine and ovine intestinal mucosal heparins. These techniques include structural analysis by nuclear magnetic resonance spectrometry, disaccharide compositional analysis, bottom-up analysis of tetrasaccharides corresponding to heparin’s antithrombin III binding site. Chemometric analysis was then applied to understand how these structural differences to predict the animal/tissue source of heparin and to help detect blending of heparins from various sources." @default.
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• W2899350018 date "2019-02-01" @default.
• W2899350018 modified "2023-10-18" @default.
• W2899350018 title "Chemometric analysis of porcine, bovine and ovine heparins" @default.
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• W2899350018 doi "https://doi.org/10.1016/j.jpba.2018.10.052" @default.
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