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• W2899360037 abstract "<b><i>Background:</i></b> The pathophysiology of intraventricular hemorrhage (IVH) is multifactorial. This study attempts to identify genetic and clinical factors contributing to IVH in newborns with a focus on those born ≤28 weeks of gestation. <b><i>Methods:</i></b> This was a prospective study of 382 consecutive newborns admitted to the neonatal intensive care unit. DNA purification was conducted using standard methods. TaqMan SNP assays were conducted for functional polymorphisms in <i>VEGF</i> (RS699947, RS2010963, RS3025039, and RS1570360) and <i>MMP2</i> (RS243685 and RS2285053) genes. An RFLP assay was done for a polymorphism in <i>MMP9</i> (RS3918242). <b><i>Results:</i></b> The GG genotype in <i>VEGF</i> RS1570360 (<i>p</i> = 0.013) and the CC genotype in <i>VEGF</i> RS699947 (<i>p</i> = 0.036) were associated with a lower incidence of IVH amongst newborns ≤28 weeks of gestation. Chorioamnionitis, Caucasian race, and patent ductus arteriosus were associated with a higher incidence of IVH. A binary logistic regression analysis of clinical and SNP data that was significant from bivariate analysis demonstrated that <i>VEGF</i> RS1570360 was significantly associated with IVH (<i>p</i> = 0.017). <b><i>Conclusion:</i></b> This study demonstrated that the GA/AA genotype in <i>VEGF</i> RS1570360 and the AA/AC genotype in <i>VEGF</i> RS699947 were associated with higher incidence rates of IVH in newborns ≤28 weeks of gestation. A future study is warranted to comprehensively examine <i>VEGF</i> polymorphisms in association with IVH." @default.
• W2899360037 created "2018-11-09" @default.
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• W2899360037 date "2018-01-01" @default.
• W2899360037 modified "2023-10-16" @default.
• W2899360037 title "Can Functional Polymorphisms in VEGF and MMP Predict Intraventricular Hemorrhage in Extremely Preterm Newborns?" @default.
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• W2899360037 doi "https://doi.org/10.1159/000493788" @default.
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