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• W2899360305 abstract "Brucellosis is a bacterial disease caused by species of the Brucella genus and affects a wide variety of domestic and wildlife species and is also an important zoonosis. The global burden of disease is difficult to assess but Brucella spp. have a worldwide distribution and are endemic in the Middle East, Africa, South America, and Asia. The clinical signs of fever and malaise are nonspecific, and the available serological diagnostic tests lack a high degree specificity in endemic regions compared to other important public health diseases such as malaria. A better understanding of the pathogenesis of brucellosis through discoveries in animal models could lead to improved diagnostics and potentially a vaccine for human use. Mouse models have played an important role in elucidating the pathogenesis but do not replicate key features of the disease such as fever. Guinea pigs were instrumental in exploring the pathogenesis of brucellosis in the early nineteenth century and could offer an improvement on the mouse model as a model for human brucellosis." @default.
• W2899360305 created "2018-11-09" @default.
• W2899360305 creator A5057237335 @default.
• W2899360305 creator A5085468774 @default.
• W2899360305 date "2018-10-31" @default.
• W2899360305 modified "2023-09-26" @default.
• W2899360305 title "A Neglected Animal Model for a Neglected Disease: Guinea Pigs and the Search for an Improved Animal Model for Human Brucellosis" @default.
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• W2899360305 doi "https://doi.org/10.3389/fmicb.2018.02593" @default.
• W2899360305 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6220108" @default.
• W2899360305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30429834" @default.
• W2899360305 hasPublicationYear "2018" @default.
• W2899360305 type Work @default.
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• W2899360305 citedByCount "8" @default.

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