Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899360977> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2899360977 abstract "Super-enhancers or stretch enhancers are clusters of active enhancers that often coordinate cell-type specific gene regulation during development and differentiation. In addition, the enrichment of disease-associated single nucleotide polymorphism in super-enhancers indicates their critical function in disease-specific gene regulation. However, little is known about the function of super-enhancers beyond gene regulation. In this study, through a comprehensive analysis of super-enhancers in 30 human cell/tissue types, we identified a new class of super-enhancers which are constitutively active across most cell/tissue types. These ‘common’ super-enhancers are associated with universally highly expressed genes in contrast to the canonical definition of super-enhancers that assert cell-type specific gene regulation. In addition, the genome sequence of these super-enhancers is highly conserved by evolution and among humans, advocating their universal function in genome regulation. Integrative analysis of 3D chromatin loops demonstrates that, in comparison to the cell-type specific super-enhancers, the cell-type common super-enhancers present a striking association with rapidly recovering loops. In this study, we propose that a new class of super-enhancers may play an important role in the early establishment of 3D chromatin structure." @default.
- W2899360977 created "2018-11-09" @default.
- W2899360977 creator A5013962324 @default.
- W2899360977 creator A5017634865 @default.
- W2899360977 creator A5076560493 @default.
- W2899360977 creator A5080272556 @default.
- W2899360977 creator A5082989514 @default.
- W2899360977 date "2019-03-01" @default.
- W2899360977 modified "2023-10-10" @default.
- W2899360977 title "A new class of constitutively active super-enhancers is associated with fast recovery of 3D chromatin loops" @default.
- W2899360977 cites W1963740134 @default.
- W2899360977 cites W1969161156 @default.
- W2899360977 cites W1971578941 @default.
- W2899360977 cites W1978329681 @default.
- W2899360977 cites W2060484997 @default.
- W2899360977 cites W2072153595 @default.
- W2899360977 cites W2076154138 @default.
- W2899360977 cites W2079407198 @default.
- W2899360977 cites W2103441770 @default.
- W2899360977 cites W2158217645 @default.
- W2899360977 cites W2171808845 @default.
- W2899360977 cites W2280788332 @default.
- W2899360977 cites W2481029670 @default.
- W2899360977 cites W2761461280 @default.
- W2899360977 cites W2794373321 @default.
- W2899360977 doi "https://doi.org/10.1186/s12859-019-2646-3" @default.
- W2899360977 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6439976" @default.
- W2899360977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30925856" @default.
- W2899360977 hasPublicationYear "2019" @default.
- W2899360977 type Work @default.
- W2899360977 sameAs 2899360977 @default.
- W2899360977 citedByCount "12" @default.
- W2899360977 countsByYear W28993609772020 @default.
- W2899360977 countsByYear W28993609772021 @default.
- W2899360977 countsByYear W28993609772022 @default.
- W2899360977 countsByYear W28993609772023 @default.
- W2899360977 crossrefType "journal-article" @default.
- W2899360977 hasAuthorship W2899360977A5013962324 @default.
- W2899360977 hasAuthorship W2899360977A5017634865 @default.
- W2899360977 hasAuthorship W2899360977A5076560493 @default.
- W2899360977 hasAuthorship W2899360977A5080272556 @default.
- W2899360977 hasAuthorship W2899360977A5082989514 @default.
- W2899360977 hasBestOaLocation W28993609771 @default.
- W2899360977 hasConcept C104317684 @default.
- W2899360977 hasConcept C111936080 @default.
- W2899360977 hasConcept C141231307 @default.
- W2899360977 hasConcept C1491633281 @default.
- W2899360977 hasConcept C165864922 @default.
- W2899360977 hasConcept C189014844 @default.
- W2899360977 hasConcept C21784809 @default.
- W2899360977 hasConcept C54355233 @default.
- W2899360977 hasConcept C70721500 @default.
- W2899360977 hasConcept C83640560 @default.
- W2899360977 hasConcept C86339819 @default.
- W2899360977 hasConcept C86803240 @default.
- W2899360977 hasConceptScore W2899360977C104317684 @default.
- W2899360977 hasConceptScore W2899360977C111936080 @default.
- W2899360977 hasConceptScore W2899360977C141231307 @default.
- W2899360977 hasConceptScore W2899360977C1491633281 @default.
- W2899360977 hasConceptScore W2899360977C165864922 @default.
- W2899360977 hasConceptScore W2899360977C189014844 @default.
- W2899360977 hasConceptScore W2899360977C21784809 @default.
- W2899360977 hasConceptScore W2899360977C54355233 @default.
- W2899360977 hasConceptScore W2899360977C70721500 @default.
- W2899360977 hasConceptScore W2899360977C83640560 @default.
- W2899360977 hasConceptScore W2899360977C86339819 @default.
- W2899360977 hasConceptScore W2899360977C86803240 @default.
- W2899360977 hasIssue "S3" @default.
- W2899360977 hasLocation W28993609771 @default.
- W2899360977 hasLocation W28993609772 @default.
- W2899360977 hasLocation W28993609773 @default.
- W2899360977 hasLocation W28993609774 @default.
- W2899360977 hasLocation W28993609775 @default.
- W2899360977 hasOpenAccess W2899360977 @default.
- W2899360977 hasPrimaryLocation W28993609771 @default.
- W2899360977 hasRelatedWork W1986586739 @default.
- W2899360977 hasRelatedWork W2187435303 @default.
- W2899360977 hasRelatedWork W2549332635 @default.
- W2899360977 hasRelatedWork W2600490673 @default.
- W2899360977 hasRelatedWork W2745126693 @default.
- W2899360977 hasRelatedWork W2899360977 @default.
- W2899360977 hasRelatedWork W2995500456 @default.
- W2899360977 hasRelatedWork W4213151014 @default.
- W2899360977 hasRelatedWork W4312387401 @default.
- W2899360977 hasRelatedWork W4321600262 @default.
- W2899360977 hasVolume "20" @default.
- W2899360977 isParatext "false" @default.
- W2899360977 isRetracted "false" @default.
- W2899360977 magId "2899360977" @default.
- W2899360977 workType "article" @default.