FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899366946> ?p ?o ?g. }

• W2899366946 endingPage "305" @default.
• W2899366946 startingPage "295" @default.
• W2899366946 abstract "The endogenous fibrinolytic system serves to prevent lasting thrombotic occlusion and infarction following initiation of coronary thrombosis. We aimed to determine whether impaired endogenous fibrinolysis can identify patients with ST-segment elevation myocardial infarction (STEMI) who remain at high cardiovascular risk despite dual antiplatelet therapy (DAPT).A prospective, observational study was conducted in 496 patients presenting with STEMI for primary percutaneous coronary intervention (PPCI). Blood was tested on arrival pre-PPCI, at discharge and at 30 days to assess thrombotic status using the automated point-of-care global thrombosis test and patients followed for 1 year for major adverse cardiovascular events (MACEs). Endogenous fibrinolysis was significantly impaired [baseline lysis time (LT) ≥2500 s] in 14% of patients and was highly predictive of recurrent MACE [hazard ratio (HR) 9.1, 95% confidence interval (CI) 5.29-15.75; P < 0.001], driven by cardiovascular death (HR 18.5, 95% CI 7.69-44.31; P < 0.001) and myocardial infarction (HR 6.2, 95% CI 2.64-14.73; P < 0.001), particularly within 30 days. Fibrinolysis remained strongly predictive of MACE after adjustment for conventional risk factors (HR 8.03, 95% CI 4.28-15.03; P < 0.001). Net reclassification showed that adding impaired fibrinolysis improved the prediction of recurrent MACE by >50% (P < 0.001). Patients with spontaneous ST-segment resolution pre-PPCI had more rapid, effective fibrinolysis [LT 1050 (1004-1125) s vs. 1501 (1239-1997) s, P < 0.001] than those without. Lysis time was not altered by standard of care STEMI treatment including DAPT and was unchanged at 30 days.Endogenous fibrinolysis assessment can identify patients with STEMI who remain at very high cardiovascular risk despite PPCI and DAPT. Further studies are needed to assess whether these patients may benefit from additional, personalized antithrombotic/anticoagulant medication to reduce future cardiovascular risk.http://www.clinicaltrials.gov. Unique identifier: NCT02562690." @default.
• W2899366946 created "2018-11-09" @default.
• W2899366946 creator A5015718599 @default.
• W2899366946 creator A5022994094 @default.
• W2899366946 creator A5031921258 @default.
• W2899366946 creator A5041477606 @default.
• W2899366946 creator A5048586453 @default.
• W2899366946 creator A5048682259 @default.
• W2899366946 creator A5078806480 @default.
• W2899366946 date "2018-10-30" @default.
• W2899366946 modified "2023-10-16" @default.
• W2899366946 title "Impaired endogenous fibrinolysis in ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention is a predictor of recurrent cardiovascular events: the RISK PPCI study" @default.
• W2899366946 cites W1958899625 @default.
• W2899366946 cites W1999796100 @default.
• W2899366946 cites W2002644581 @default.
• W2899366946 cites W2054753031 @default.
• W2899366946 cites W2058071560 @default.
• W2899366946 cites W2058326090 @default.
• W2899366946 cites W2058419216 @default.
• W2899366946 cites W2063898140 @default.
• W2899366946 cites W2108386972 @default.
• W2899366946 cites W2116209993 @default.
• W2899366946 cites W2117677020 @default.
• W2899366946 cites W2134322421 @default.
• W2899366946 cites W2143203161 @default.
• W2899366946 cites W2147571168 @default.
• W2899366946 cites W2152426641 @default.
• W2899366946 cites W2155296050 @default.
• W2899366946 cites W2160357187 @default.
• W2899366946 cites W2166950143 @default.
• W2899366946 cites W2205148277 @default.
• W2899366946 cites W230645541 @default.
• W2899366946 cites W2337665873 @default.
• W2899366946 cites W2408538721 @default.
• W2899366946 cites W2564137099 @default.
• W2899366946 cites W2613753174 @default.
• W2899366946 cites W2749380187 @default.
• W2899366946 cites W2753982478 @default.
• W2899366946 cites W2761849912 @default.
• W2899366946 cites W2763753360 @default.
• W2899366946 cites W2789512318 @default.
• W2899366946 doi "https://doi.org/10.1093/eurheartj/ehy656" @default.
• W2899366946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30380032" @default.
• W2899366946 hasPublicationYear "2018" @default.
• W2899366946 type Work @default.
• W2899366946 sameAs 2899366946 @default.
• W2899366946 citedByCount "50" @default.
• W2899366946 countsByYear W28993669462018 @default.
• W2899366946 countsByYear W28993669462019 @default.
• W2899366946 countsByYear W28993669462020 @default.
• W2899366946 countsByYear W28993669462021 @default.
• W2899366946 countsByYear W28993669462022 @default.
• W2899366946 countsByYear W28993669462023 @default.
• W2899366946 crossrefType "journal-article" @default.
• W2899366946 hasAuthorship W2899366946A5015718599 @default.
• W2899366946 hasAuthorship W2899366946A5022994094 @default.
• W2899366946 hasAuthorship W2899366946A5031921258 @default.
• W2899366946 hasAuthorship W2899366946A5041477606 @default.
• W2899366946 hasAuthorship W2899366946A5048586453 @default.
• W2899366946 hasAuthorship W2899366946A5048682259 @default.
• W2899366946 hasAuthorship W2899366946A5078806480 @default.
• W2899366946 hasBestOaLocation W28993669461 @default.
• W2899366946 hasConcept C126322002 @default.
• W2899366946 hasConcept C164705383 @default.
• W2899366946 hasConcept C207103383 @default.
• W2899366946 hasConcept C2776825266 @default.
• W2899366946 hasConcept C2777995511 @default.
• W2899366946 hasConcept C2780400711 @default.
• W2899366946 hasConcept C2780739214 @default.
• W2899366946 hasConcept C44249647 @default.
• W2899366946 hasConcept C500558357 @default.
• W2899366946 hasConcept C71924100 @default.
• W2899366946 hasConceptScore W2899366946C126322002 @default.
• W2899366946 hasConceptScore W2899366946C164705383 @default.
• W2899366946 hasConceptScore W2899366946C207103383 @default.
• W2899366946 hasConceptScore W2899366946C2776825266 @default.
• W2899366946 hasConceptScore W2899366946C2777995511 @default.
• W2899366946 hasConceptScore W2899366946C2780400711 @default.
• W2899366946 hasConceptScore W2899366946C2780739214 @default.
• W2899366946 hasConceptScore W2899366946C44249647 @default.
• W2899366946 hasConceptScore W2899366946C500558357 @default.
• W2899366946 hasConceptScore W2899366946C71924100 @default.
• W2899366946 hasIssue "3" @default.
• W2899366946 hasLocation W28993669461 @default.
• W2899366946 hasLocation W28993669462 @default.
• W2899366946 hasLocation W28993669463 @default.
• W2899366946 hasOpenAccess W2899366946 @default.
• W2899366946 hasPrimaryLocation W28993669461 @default.
• W2899366946 hasRelatedWork W2034570615 @default.
• W2899366946 hasRelatedWork W2218936584 @default.
• W2899366946 hasRelatedWork W2542074903 @default.
• W2899366946 hasRelatedWork W2766108442 @default.
• W2899366946 hasRelatedWork W2794692108 @default.
• W2899366946 hasRelatedWork W2974979968 @default.
• W2899366946 hasRelatedWork W3028900695 @default.
• W2899366946 hasRelatedWork W3197198654 @default.
• W2899366946 hasRelatedWork W4323364680 @default.
• W2899366946 hasRelatedWork W3144615962 @default.

• next