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- W2899370893 abstract "In patients with colorectal peritoneal metastases (PM), the use of cytoreductive surgery (CRS) and HIPEC with oxaliplatin (OX) is increasingly used. The results of the recently reported randomized Prodige 7 trial failed to show a difference in overall survival between patients undergoing CRS alone versus CRS combined with HIPEC using high dose OX. The trial was not designed or powered, however, to detect a potentially clinically meaningful benefit in locoregional disease control. Here, I address some potential explanations for the lack of benefit in the Prodige 7 trial, including OX efficacy issues, adverse effects of intraperitoneal high dose glucose, and potential drawbacks of the use of hyperthermia." @default.
- W2899370893 created "2018-11-09" @default.
- W2899370893 creator A5042130353 @default.
- W2899370893 date "2019-03-01" @default.
- W2899370893 modified "2023-10-12" @default.
- W2899370893 title "HIPEC with oxaliplatin for colorectal peritoneal metastasis: The end of the road?" @default.
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- W2899370893 doi "https://doi.org/10.1016/j.ejso.2018.10.542" @default.
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