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- W2899371333 abstract "The University of Virginia /Padova Type 1 Diabetes (TID) simulator has been widely used for testing artificial pancreas controllers, and, recently, novel insulin formulations and glucose sensors. However, a module describing the pharmacokinetics of the new long-acting insulin analogues is not available. The aim of this contribution is to reproduce multiple daily insulin injection (MDI) therapy, with insulin glargine 100 U/mL (Gla-100) as basal insulin, using the TID simulator. This was achieved by developing a model of Gla-100 and by incorporating it into the simulator. The methodology described here can be extended to other insulins, allowing an extensive in silico testing of different long-acting insulin analogues under various settings before starting human trials." @default.
- W2899371333 created "2018-11-09" @default.
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- W2899371333 date "2018-07-01" @default.
- W2899371333 modified "2023-10-06" @default.
- W2899371333 title "Long-acting Insulin in Diabetes Therapy: In Silico Clinical Trials with the UVA/Padova Type 1 Diabetes Simulator*" @default.
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- W2899371333 doi "https://doi.org/10.1109/embc.2018.8513234" @default.
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