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• W2899396007 endingPage "410" @default.
• W2899396007 startingPage "380" @default.
• W2899396007 abstract "Background:: The discovery of cisplatin and the subsequent research revealed the importance of dinitrogen-containing moiety for the anticancer action of metal complexes. Moreover, certain diamine ligands alone display cytotoxicity that contributes to the overall activity of corresponding complexes. Objective:: To summarize the current knowledge on the anticancer efficacy, selectivity, and the mechanisms of action of metal complexes with various types of diamine ligands. Method:: The contribution of aliphatic acyclic, aliphatic cyclic, and aromatic diamine ligands to the anticancer activity and selectivity/toxicity of metal complexes with different metal ions were analyzed by comparison with organic ligand alone and/or conventional platinum-based chemotherapeutics. Results:: The aliphatic acyclic diamine ligands are present mostly in complexes with platinum. Aliphatic cyclic diamines are part of Pt(II), Ru(II) and Au(III) complexes, while aromatic diamine ligands are found in Pt(II), Ru(II), Pd(II) and Ir(III) complexes. The type and oxidation state of metal ions greatly influences the cytotoxicity of metal complexes with aliphatic acyclic diamine ligands. Lipophilicity of organic ligands, dependent on alkyl-side chain length and structure, determines their cellular uptake, with edda and eddp/eddip ligands being most useful in this regard. Aliphatic cyclic diamine ligands improved the activity/toxicity ratio of oxaliplatin-type complexes. The complexes with aromatic diamine ligands remain unexplored regarding their anticancer mechanism. The investigated complexes mainly caused apoptotic or necrotic cell death. Conclusion:: Metal complexes with diamine ligands are promising candidates for efficient and more selective alternatives to conventional platinum-based chemotherapeutics. Further research is required to reveal the chemico-physical properties and molecular mechanisms underlying their biological activity." @default.
• W2899396007 created "2018-11-09" @default.
• W2899396007 creator A5013088771 @default.
• W2899396007 creator A5034062879 @default.
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• W2899396007 creator A5070648885 @default.
• W2899396007 creator A5073187677 @default.
• W2899396007 creator A5079920637 @default.
• W2899396007 date "2020-02-19" @default.
• W2899396007 modified "2023-10-14" @default.
• W2899396007 title "Current Development of Metal Complexes with Diamine Ligands as Potential Anticancer Agents" @default.
• W2899396007 cites W1545931334 @default.
• W2899396007 cites W1964142370 @default.
• W2899396007 cites W1964547337 @default.
• W2899396007 cites W1975104632 @default.
• W2899396007 cites W1975397475 @default.
• W2899396007 cites W1979034486 @default.
• W2899396007 cites W1983538439 @default.
• W2899396007 cites W1983842294 @default.
• W2899396007 cites W1984265550 @default.
• W2899396007 cites W1989399551 @default.
• W2899396007 cites W1992449892 @default.
• W2899396007 cites W1994256876 @default.
• W2899396007 cites W2000010430 @default.
• W2899396007 cites W2000991764 @default.
• W2899396007 cites W2002503642 @default.
• W2899396007 cites W2004292938 @default.
• W2899396007 cites W2005209160 @default.
• W2899396007 cites W2005837194 @default.
• W2899396007 cites W2006697292 @default.
• W2899396007 cites W2007732152 @default.
• W2899396007 cites W2008175370 @default.
• W2899396007 cites W2008434588 @default.
• W2899396007 cites W2009190114 @default.
• W2899396007 cites W2010049076 @default.
• W2899396007 cites W2010504362 @default.
• W2899396007 cites W2012217882 @default.
• W2899396007 cites W2015245912 @default.
• W2899396007 cites W2015940443 @default.
• W2899396007 cites W2018165233 @default.
• W2899396007 cites W2021356848 @default.
• W2899396007 cites W2021801206 @default.
• W2899396007 cites W2022275454 @default.
• W2899396007 cites W2024297892 @default.
• W2899396007 cites W2025935436 @default.
• W2899396007 cites W2026229896 @default.
• W2899396007 cites W2027274277 @default.
• W2899396007 cites W2028852313 @default.
• W2899396007 cites W2032608114 @default.
• W2899396007 cites W2034072203 @default.
• W2899396007 cites W2039265299 @default.
• W2899396007 cites W2041140811 @default.
• W2899396007 cites W2042152347 @default.
• W2899396007 cites W2043057215 @default.
• W2899396007 cites W2045226712 @default.
• W2899396007 cites W2048168597 @default.
• W2899396007 cites W2048399045 @default.
• W2899396007 cites W2051016793 @default.
• W2899396007 cites W2053357425 @default.
• W2899396007 cites W2053789576 @default.
• W2899396007 cites W2054938647 @default.
• W2899396007 cites W2055643866 @default.
• W2899396007 cites W2058309061 @default.
• W2899396007 cites W2063180542 @default.
• W2899396007 cites W2064929404 @default.
• W2899396007 cites W2069187831 @default.
• W2899396007 cites W2069305922 @default.
• W2899396007 cites W2069699183 @default.
• W2899396007 cites W2072861812 @default.
• W2899396007 cites W2078910722 @default.
• W2899396007 cites W2082801502 @default.
• W2899396007 cites W2088405479 @default.
• W2899396007 cites W2091772550 @default.
• W2899396007 cites W2094999387 @default.
• W2899396007 cites W2097607581 @default.
• W2899396007 cites W2101539565 @default.
• W2899396007 cites W2101623805 @default.
• W2899396007 cites W2102011234 @default.
• W2899396007 cites W2115309273 @default.
• W2899396007 cites W2120853161 @default.
• W2899396007 cites W2127273968 @default.
• W2899396007 cites W2131250428 @default.
• W2899396007 cites W2132293722 @default.
• W2899396007 cites W2138558295 @default.
• W2899396007 cites W2148804499 @default.
• W2899396007 cites W2149667224 @default.
• W2899396007 cites W2156337847 @default.
• W2899396007 cites W2160477620 @default.
• W2899396007 cites W2161293852 @default.
• W2899396007 cites W2194208904 @default.
• W2899396007 cites W2320466347 @default.
• W2899396007 cites W2321148088 @default.
• W2899396007 cites W2336077388 @default.
• W2899396007 cites W2522556924 @default.
• W2899396007 cites W2548673699 @default.
• W2899396007 cites W2575614372 @default.
• W2899396007 cites W2586922530 @default.
• W2899396007 cites W2604272192 @default.

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