FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899404792> ?p ?o ?g. }

• W2899404792 endingPage "35" @default.
• W2899404792 startingPage "22" @default.
• W2899404792 abstract "Galectin-9 is the most potent inducer of cell death in lymphomas and other malignant cell types among the members of the galectin family. We investigated the mechanism of galectin-9-induced cell death in PC-3 prostate cancer cells in comparison with in Jurkat T cells. Galectin-9 induced apoptotic cell death in Jurkat cells, as typically revealed by DNA ladder formation. On the other hand, DNA ladder formation and other features of apoptosis were not apparent in PC-3 cells undergoing galectin-9-induced death. Exogenous galectin-9 was endocytosed and destined to the lysosomal compartment in PC-3 cells. The internalized galectin-9 was resistant to detergent solubilization but was solubilized with lactose. Agents inhibiting actin filament dynamics abolished the internalization and cytocidal effect of galectin-9 in PC-3 but not Jurkat cells. Galectin-9 induced accumulation of ubiquitinated proteins, possibly heterogeneously ubiquitinated and/or monoubiquitinated proteins, in PC-3 cells. PYR-41, an inhibitor of the ubiquitin-activating E1 enzyme, suppressed the cytocidal effect of galectin-9. Although ubiquitination was upregulated also in Jurkat cells by galectin-9, PYR-41 was ineffective against galectin-9-induced cell death. Colocalization of ubiquitinated proteins and LAMP-1 was detectable in PC-3 cells treated with galectin-9. The ubiquitinated proteins were recovered in the insoluble fraction upon cell fractionation. In contrast, ubiquitinated proteins that accumulated after treatment with proteasome inhibitors did not co-localize with LAMP-1 and were mainly recovered in soluble fraction. The results suggest that atypical ubiquitination and accumulation of ubiquitinated proteins in lysosomes play a pivotal role in galectin-9-induced non-apoptotic death in PC-3 cells." @default.
• W2899404792 created "2018-11-09" @default.
• W2899404792 creator A5003277182 @default.
• W2899404792 creator A5045343631 @default.
• W2899404792 creator A5065894696 @default.
• W2899404792 creator A5066291977 @default.
• W2899404792 creator A5089516155 @default.
• W2899404792 date "2018-11-22" @default.
• W2899404792 modified "2023-10-14" @default.
• W2899404792 title "Galectin-9 induces atypical ubiquitination leading to cell death in PC-3 prostate cancer cells" @default.
• W2899404792 cites W1585589080 @default.
• W2899404792 cites W1754972901 @default.
• W2899404792 cites W1966193262 @default.
• W2899404792 cites W1966194999 @default.
• W2899404792 cites W1977099149 @default.
• W2899404792 cites W1980333945 @default.
• W2899404792 cites W1983523339 @default.
• W2899404792 cites W1985997449 @default.
• W2899404792 cites W2029962300 @default.
• W2899404792 cites W2030194584 @default.
• W2899404792 cites W2035187088 @default.
• W2899404792 cites W2035759292 @default.
• W2899404792 cites W2039763079 @default.
• W2899404792 cites W2047247630 @default.
• W2899404792 cites W2053289663 @default.
• W2899404792 cites W2053608295 @default.
• W2899404792 cites W2059799534 @default.
• W2899404792 cites W2068473916 @default.
• W2899404792 cites W2070631889 @default.
• W2899404792 cites W2072772016 @default.
• W2899404792 cites W2088516970 @default.
• W2899404792 cites W2100368894 @default.
• W2899404792 cites W2109691647 @default.
• W2899404792 cites W2118725525 @default.
• W2899404792 cites W2123886524 @default.
• W2899404792 cites W2125013655 @default.
• W2899404792 cites W2135655382 @default.
• W2899404792 cites W2140915719 @default.
• W2899404792 cites W2147917253 @default.
• W2899404792 cites W2150280909 @default.
• W2899404792 cites W2165659145 @default.
• W2899404792 cites W2525950393 @default.
• W2899404792 cites W2561784300 @default.
• W2899404792 doi "https://doi.org/10.1093/glycob/cwy099" @default.
• W2899404792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30383222" @default.
• W2899404792 hasPublicationYear "2018" @default.
• W2899404792 type Work @default.
• W2899404792 sameAs 2899404792 @default.
• W2899404792 citedByCount "11" @default.
• W2899404792 countsByYear W28994047922020 @default.
• W2899404792 countsByYear W28994047922021 @default.
• W2899404792 countsByYear W28994047922022 @default.
• W2899404792 countsByYear W28994047922023 @default.
• W2899404792 crossrefType "journal-article" @default.
• W2899404792 hasAuthorship W2899404792A5003277182 @default.
• W2899404792 hasAuthorship W2899404792A5045343631 @default.
• W2899404792 hasAuthorship W2899404792A5065894696 @default.
• W2899404792 hasAuthorship W2899404792A5066291977 @default.
• W2899404792 hasAuthorship W2899404792A5089516155 @default.
• W2899404792 hasBestOaLocation W28994047921 @default.
• W2899404792 hasConcept C104317684 @default.
• W2899404792 hasConcept C121608353 @default.
• W2899404792 hasConcept C1491633281 @default.
• W2899404792 hasConcept C153911025 @default.
• W2899404792 hasConcept C156293190 @default.
• W2899404792 hasConcept C179464577 @default.
• W2899404792 hasConcept C185592680 @default.
• W2899404792 hasConcept C190283241 @default.
• W2899404792 hasConcept C203014093 @default.
• W2899404792 hasConcept C25602115 @default.
• W2899404792 hasConcept C2776090121 @default.
• W2899404792 hasConcept C2778735756 @default.
• W2899404792 hasConcept C31573885 @default.
• W2899404792 hasConcept C54355233 @default.
• W2899404792 hasConcept C55493867 @default.
• W2899404792 hasConcept C86803240 @default.
• W2899404792 hasConcept C8891405 @default.
• W2899404792 hasConcept C95444343 @default.
• W2899404792 hasConcept C96232424 @default.
• W2899404792 hasConceptScore W2899404792C104317684 @default.
• W2899404792 hasConceptScore W2899404792C121608353 @default.
• W2899404792 hasConceptScore W2899404792C1491633281 @default.
• W2899404792 hasConceptScore W2899404792C153911025 @default.
• W2899404792 hasConceptScore W2899404792C156293190 @default.
• W2899404792 hasConceptScore W2899404792C179464577 @default.
• W2899404792 hasConceptScore W2899404792C185592680 @default.
• W2899404792 hasConceptScore W2899404792C190283241 @default.
• W2899404792 hasConceptScore W2899404792C203014093 @default.
• W2899404792 hasConceptScore W2899404792C25602115 @default.
• W2899404792 hasConceptScore W2899404792C2776090121 @default.
• W2899404792 hasConceptScore W2899404792C2778735756 @default.
• W2899404792 hasConceptScore W2899404792C31573885 @default.
• W2899404792 hasConceptScore W2899404792C54355233 @default.
• W2899404792 hasConceptScore W2899404792C55493867 @default.
• W2899404792 hasConceptScore W2899404792C86803240 @default.
• W2899404792 hasConceptScore W2899404792C8891405 @default.
• W2899404792 hasConceptScore W2899404792C95444343 @default.
• W2899404792 hasConceptScore W2899404792C96232424 @default.

• next