FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899426761> ?p ?o ?g. }

• W2899426761 endingPage "164" @default.
• W2899426761 startingPage "156" @default.
• W2899426761 abstract "Here we present an empirical study that provides a basis for understanding the impact of the social environment on individuals with mental disorders. Rats treated chronically with the dopamine-agonist quinpirole offer a solid animal model for compulsive behavior that has been comprehensively evaluated and validated in numerous studies. Moreover, the method of behavioral analysis used in the quinpirole rat model has been similarly applied to the analysis of compulsive rituals in OCD patients, revealing similarities to the structure of compulsions in the quinpirole-sensitized rats. Here, we examined how compulsive checking by quinpirole-sensitized rats was modulated by the presence of a partner that was also treated with quinpirole or a partner that was treated with saline, compared to the typical expression of compulsive checking shown by rats tested alone. Our results demonstrate that the presence of a partner does indeed modulate the performance of checking behavior. Specifically, the vigor of compulsive checking was attenuated in the presence of a saline-treated partner, and augmented in the presence of a quinpirole-treated partner. This finding provides compelling evidence that social interactions modulate the expression of compulsive checking in the quinpirole rat model of OCD. This uncovering of the effectiveness of social modulation, indicates the quinpirole preparation as a paradigm for investigating the mechanisms by which the social environment modulates the development and expression of OCD. More generally, it presents a paradigm for the study of the influence of drug effects as a function of social interaction." @default.
• W2899426761 created "2018-11-09" @default.
• W2899426761 creator A5075170543 @default.
• W2899426761 creator A5085834914 @default.
• W2899426761 creator A5087536174 @default.
• W2899426761 date "2019-02-01" @default.
• W2899426761 modified "2023-10-03" @default.
• W2899426761 title "Social interaction modulates the intensity of compulsive checking in a rat model of obsessive-compulsive disorder (OCD)" @default.
• W2899426761 cites W1620499250 @default.
• W2899426761 cites W1679103294 @default.
• W2899426761 cites W1918579457 @default.
• W2899426761 cites W1979567039 @default.
• W2899426761 cites W1981650653 @default.
• W2899426761 cites W1988136005 @default.
• W2899426761 cites W1988175676 @default.
• W2899426761 cites W1990549633 @default.
• W2899426761 cites W1998489561 @default.
• W2899426761 cites W2001386091 @default.
• W2899426761 cites W2007390153 @default.
• W2899426761 cites W2008145176 @default.
• W2899426761 cites W2013437572 @default.
• W2899426761 cites W2016841097 @default.
• W2899426761 cites W2017641975 @default.
• W2899426761 cites W2018376764 @default.
• W2899426761 cites W2023020227 @default.
• W2899426761 cites W2027720642 @default.
• W2899426761 cites W2032279347 @default.
• W2899426761 cites W2034136484 @default.
• W2899426761 cites W2036609721 @default.
• W2899426761 cites W2047960208 @default.
• W2899426761 cites W2058872213 @default.
• W2899426761 cites W2059194753 @default.
• W2899426761 cites W2061188228 @default.
• W2899426761 cites W2064942134 @default.
• W2899426761 cites W2076743651 @default.
• W2899426761 cites W2083806108 @default.
• W2899426761 cites W2090130900 @default.
• W2899426761 cites W2091383378 @default.
• W2899426761 cites W2091575485 @default.
• W2899426761 cites W2091738137 @default.
• W2899426761 cites W2092722926 @default.
• W2899426761 cites W2095513262 @default.
• W2899426761 cites W2106299403 @default.
• W2899426761 cites W2111905307 @default.
• W2899426761 cites W2120530707 @default.
• W2899426761 cites W2150114336 @default.
• W2899426761 cites W2150780254 @default.
• W2899426761 cites W2167756235 @default.
• W2899426761 cites W2225840906 @default.
• W2899426761 cites W2316130225 @default.
• W2899426761 cites W2341516829 @default.
• W2899426761 cites W2347147710 @default.
• W2899426761 cites W2423509797 @default.
• W2899426761 cites W2533614237 @default.
• W2899426761 cites W2538755856 @default.
• W2899426761 cites W2582550385 @default.
• W2899426761 cites W2742205278 @default.
• W2899426761 cites W2766452330 @default.
• W2899426761 cites W2769234893 @default.
• W2899426761 cites W2783334262 @default.
• W2899426761 cites W2800774713 @default.
• W2899426761 cites W2802962242 @default.
• W2899426761 cites W4210596947 @default.
• W2899426761 cites W938387690 @default.
• W2899426761 doi "https://doi.org/10.1016/j.bbr.2018.10.038" @default.
• W2899426761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30389609" @default.
• W2899426761 hasPublicationYear "2019" @default.
• W2899426761 type Work @default.
• W2899426761 sameAs 2899426761 @default.
• W2899426761 citedByCount "9" @default.
• W2899426761 countsByYear W28994267612020 @default.
• W2899426761 countsByYear W28994267612021 @default.
• W2899426761 countsByYear W28994267612022 @default.
• W2899426761 countsByYear W28994267612023 @default.
• W2899426761 crossrefType "journal-article" @default.
• W2899426761 hasAuthorship W2899426761A5075170543 @default.
• W2899426761 hasAuthorship W2899426761A5085834914 @default.
• W2899426761 hasAuthorship W2899426761A5087536174 @default.
• W2899426761 hasConcept C126322002 @default.
• W2899426761 hasConcept C137183658 @default.
• W2899426761 hasConcept C138496976 @default.
• W2899426761 hasConcept C15744967 @default.
• W2899426761 hasConcept C169760540 @default.
• W2899426761 hasConcept C170493617 @default.
• W2899426761 hasConcept C2778258207 @default.
• W2899426761 hasConcept C2778296116 @default.
• W2899426761 hasConcept C2778938600 @default.
• W2899426761 hasConcept C2779275509 @default.
• W2899426761 hasConcept C3017582312 @default.
• W2899426761 hasConcept C44208683 @default.
• W2899426761 hasConcept C513476851 @default.
• W2899426761 hasConcept C70410870 @default.
• W2899426761 hasConcept C71924100 @default.
• W2899426761 hasConceptScore W2899426761C126322002 @default.
• W2899426761 hasConceptScore W2899426761C137183658 @default.
• W2899426761 hasConceptScore W2899426761C138496976 @default.
• W2899426761 hasConceptScore W2899426761C15744967 @default.
• W2899426761 hasConceptScore W2899426761C169760540 @default.

• next