FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899454792> ?p ?o ?g. }

• W2899454792 endingPage "G178" @default.
• W2899454792 startingPage "G166" @default.
• W2899454792 abstract "Obesity can lead to impairments in hepatic glucose and insulin homeostasis, and although exercise is an effective treatment, the molecular targets remain incompletely understood. As IL-6 is an exercise-inducible cytokine, we aimed to identify whether IL-6 itself influences hepatic glucose and insulin homeostasis and whether this response differs during obesity. In vivo, male mice were fed a low-fat diet (LFD; 10% kcal) or a high-fat diet (HFD; 60% kcal) for 7 wk, which induced obesity and hepatic lipid accumulation. LFD- and HFD-fed mice were injected with IL-6 (400 ng, 75 min) or PBS and then with insulin (1 U/kg; ~15 min) or saline, at which point livers were collected. In both LFD- and HFD-fed mice, IL-6 decreased blood glucose and mRNA expression of gluconeogenic genes alongside increased phosphorylation of AKT in comparison to PBS controls, and this occurred without changes in circulating insulin. To determine whether this effect of IL-6 was directly on the liver, we completed in vitro isolated primary hepatocyte experiments from chow-fed mice and cultured with or without exposure to free fatty acid (250 μm palmitate and 250 μm oleate, 24 h) to induce lipid accumulation. In both control and free fatty acid-treated hepatocytes, IL-6 (20 ng/ml, 75 min) slightly attenuated insulin-stimulated (10 nM; ~15 min) AKT phosphorylation. Together, these data suggest that IL-6 may lead to improvements in indices of hepatic glucose and insulin homeostasis in vivo; however, this is likely due to an indirect effect on the hepatocyte. NEW & NOTEWORTHY In this study, we used lean and obese mice and found that a single injection of IL-6 improved glucose tolerance, decreased hepatic gluconeogenic gene expression, and increased hepatic phosphorylation of AKT. In primary hepatocytes cultured under control and lipid-laden conditions, IL-6 had a mild, but deleterious, effect on phosphorylation of AKT. Our results show that the beneficial effects of IL-6 on glucose and insulin homeostasis, in vivo, are maintained in obesity." @default.
• W2899454792 created "2018-11-09" @default.
• W2899454792 creator A5029948307 @default.
• W2899454792 creator A5043048639 @default.
• W2899454792 creator A5057139970 @default.
• W2899454792 creator A5079202585 @default.
• W2899454792 creator A5083751352 @default.
• W2899454792 creator A5083911559 @default.
• W2899454792 creator A5087522414 @default.
• W2899454792 date "2019-01-01" @default.
• W2899454792 modified "2023-09-27" @default.
• W2899454792 title "Acute administration of IL-6 improves indices of hepatic glucose and insulin homeostasis in lean and obese mice" @default.
• W2899454792 cites W1560791558 @default.
• W2899454792 cites W1726025741 @default.
• W2899454792 cites W1833314573 @default.
• W2899454792 cites W1845255770 @default.
• W2899454792 cites W1970105405 @default.
• W2899454792 cites W1978905530 @default.
• W2899454792 cites W1989177817 @default.
• W2899454792 cites W2001600469 @default.
• W2899454792 cites W2005863133 @default.
• W2899454792 cites W2019279942 @default.
• W2899454792 cites W2026722559 @default.
• W2899454792 cites W2028035581 @default.
• W2899454792 cites W2035324964 @default.
• W2899454792 cites W2039235909 @default.
• W2899454792 cites W2043864088 @default.
• W2899454792 cites W2058919856 @default.
• W2899454792 cites W2066243203 @default.
• W2899454792 cites W2078325369 @default.
• W2899454792 cites W2081680109 @default.
• W2899454792 cites W2084456277 @default.
• W2899454792 cites W2089713062 @default.
• W2899454792 cites W2092648132 @default.
• W2899454792 cites W2093845352 @default.
• W2899454792 cites W2099540110 @default.
• W2899454792 cites W2107277218 @default.
• W2899454792 cites W2114475253 @default.
• W2899454792 cites W2116609639 @default.
• W2899454792 cites W2119519672 @default.
• W2899454792 cites W2120489134 @default.
• W2899454792 cites W2125148955 @default.
• W2899454792 cites W2125838286 @default.
• W2899454792 cites W2130078845 @default.
• W2899454792 cites W2130248772 @default.
• W2899454792 cites W2134285290 @default.
• W2899454792 cites W2147495692 @default.
• W2899454792 cites W2155824086 @default.
• W2899454792 cites W2163710303 @default.
• W2899454792 cites W2170772297 @default.
• W2899454792 cites W2322918357 @default.
• W2899454792 cites W2483304195 @default.
• W2899454792 cites W2492795909 @default.
• W2899454792 cites W2518700063 @default.
• W2899454792 cites W2548551915 @default.
• W2899454792 cites W2607410215 @default.
• W2899454792 cites W2725509061 @default.
• W2899454792 cites W2784128889 @default.
• W2899454792 cites W4232534952 @default.
• W2899454792 cites W4234984997 @default.
• W2899454792 cites W4249727000 @default.
• W2899454792 doi "https://doi.org/10.1152/ajpgi.00097.2018" @default.
• W2899454792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30383412" @default.
• W2899454792 hasPublicationYear "2019" @default.
• W2899454792 type Work @default.
• W2899454792 sameAs 2899454792 @default.
• W2899454792 citedByCount "22" @default.
• W2899454792 countsByYear W28994547922019 @default.
• W2899454792 countsByYear W28994547922020 @default.
• W2899454792 countsByYear W28994547922021 @default.
• W2899454792 countsByYear W28994547922022 @default.
• W2899454792 countsByYear W28994547922023 @default.
• W2899454792 crossrefType "journal-article" @default.
• W2899454792 hasAuthorship W2899454792A5029948307 @default.
• W2899454792 hasAuthorship W2899454792A5043048639 @default.
• W2899454792 hasAuthorship W2899454792A5057139970 @default.
• W2899454792 hasAuthorship W2899454792A5079202585 @default.
• W2899454792 hasAuthorship W2899454792A5083751352 @default.
• W2899454792 hasAuthorship W2899454792A5083911559 @default.
• W2899454792 hasAuthorship W2899454792A5087522414 @default.
• W2899454792 hasBestOaLocation W28994547921 @default.
• W2899454792 hasConcept C112446052 @default.
• W2899454792 hasConcept C11960822 @default.
• W2899454792 hasConcept C126322002 @default.
• W2899454792 hasConcept C134018914 @default.
• W2899454792 hasConcept C150903083 @default.
• W2899454792 hasConcept C185592680 @default.
• W2899454792 hasConcept C202751555 @default.
• W2899454792 hasConcept C207001950 @default.
• W2899454792 hasConcept C2776200302 @default.
• W2899454792 hasConcept C2777391703 @default.
• W2899454792 hasConcept C2779306644 @default.
• W2899454792 hasConcept C3018667095 @default.
• W2899454792 hasConcept C543025807 @default.
• W2899454792 hasConcept C55493867 @default.
• W2899454792 hasConcept C63645605 @default.
• W2899454792 hasConcept C71924100 @default.
• W2899454792 hasConcept C75217442 @default.

• next