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- W2899456802 abstract "Objectives: Our aim was to evaluate the role of inflammation-related genes in essential hypertension (EH) and blood pressure (BP) control. Methods: We analysed transcriptional activity of inflammatory mediator genes in EH patients and normotensive individuals using real-time PCR primer assays (SABiosciences, Qiagen, USA), and genotyped polymorphisms in 20 differentially expressed genes (IL10, IL1B, CXCR4, CXCR2, CCR5, CCR2, CX3CR1, CXCL1, CXCL8, IL12B, LTA, TNF, IL6, TNFRSF1A, CCL17, CCL2, CCL8, CCL16, CCL23, and CCL18) in the study group consisting of 737 men (274 patients with EH and 463 controls) of Tatar ethnic origin from the Republic of Bashkortostan (Russian Federation). We analysed association with EH and BP levels using logistic and linear regression models implemented in PLINK with age as covariate. Multilocus analysis was performed using APSampler program. FDR method was applied to adjust for multiple testing. Results: The most significant associations with EH were observed for CXCL13 rs355689*C allele (OR = 0.55, CI: 0.39–0.76, PFDR = 0.008, additive model) and CCL18 rs8073066*C allele (OR = 0.64, CI: 0.49–0.83, PFDR = 0.018, additive model). CXCL13 rs355689*C allele was associated with systolic (PFDR = 0.002, additive model) and diastolic (PFDR = 0.025, dominant model) BP levels. Multilocus analysis has revealed additional association of IL1B rs16944*T+ CXCL1 rs40748G +TNFRSF1A rs767455*G+ CCL2 rs991804*C (OR = 2.9, PFDR = 0.01) and CX3CR1 rs3732378*T+ CXCL13 rs355689*C + CCL17 rs223828*T (OR = 0.22, PFDR = 0.001) combinations with EH. Conclusion: Using expression profiling, we detected differential transcriptional activity of 20 inflammation-related genes in EH patients, and found the association of the two of them (CXCL13 and CCL18) with the EH risk. Our findings suggest the implication of chemokines in hypertension." @default.
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- W2899456802 date "2018-10-01" @default.
- W2899456802 modified "2023-09-27" @default.
- W2899456802 title "A8491 CXCL1 3 and CCL18 genes are associated with essential hypertension in Tatars from Russia" @default.
- W2899456802 doi "https://doi.org/10.1097/01.hjh.0000548207.60119.27" @default.
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