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- W2899457671 endingPage "9422" @default.
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- W2899457671 abstract "The gut microbiota has emerged as a critical player in shaping and modulating brain function and has been shown to influence numerous behaviors, including anxiety and depression-like behaviors, sociability, and cognition. However, the effects of the gut microbiota on specific disorders associated with thalamo-cortico-basal ganglia circuits, ranging from compulsive behavior and addiction to altered sensation and motor output, are only recently being explored. Wholesale depletion and alteration of gut microbial communities in rodent models of disorders, such as Parkinson's disease, autism, and addiction, robustly affect movement and motivated behavior. A new frontier therefore lies in identifying specific microbial alterations that affect these behaviors and understanding the underlying mechanisms of action. Comparing alterations in gut microbiota across multiple basal-ganglia associated disease states allows for identification of common mechanistic pathways that may interact with distinct environmental and genetic risk factors to produce disease-specific outcomes." @default.
- W2899457671 created "2018-11-09" @default.
- W2899457671 creator A5016883027 @default.
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- W2899457671 creator A5039017085 @default.
- W2899457671 creator A5053261329 @default.
- W2899457671 creator A5058647225 @default.
- W2899457671 date "2018-10-31" @default.
- W2899457671 modified "2023-10-16" @default.
- W2899457671 title "Defining Dysbiosis in Disorders of Movement and Motivation" @default.
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