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- W2899461507 abstract "Objectives: To compare the efficacy and safety of long-acting nifedipine with other antihypertensive drugs in adult hypertensive patients. Methods: Based on the PICO framework all the databases including Clinicaltrials.gov were searched for the randomised clinical trials (RCTs) reporting a decrease in blood pressure (BP) with long-acting nifedipine and other major anti-hypertensives. The PRISMA guidelines and Cochrane's risk assessment tool were used to perform Quality assessment and risk bias. Results: A total of 39 studies consisting of 10, 689 hypertension patients aged between 18–65 years were included in the final analysis. Among the different treatment groups, the mean systolic BP (SBP) at baseline ranged between 152.13 ± 7.5–161.8 ± 0.0 mm Hg and the diastolic BP (DBP) ranged between 95.88 ± 6.62–102.2 ± 0.0 mm Hg. The long-acting nifedipine demonstrated a greater reduction in SBP and DBP in comparison to angiotensin converting enzyme inhibitors (ACEIs) [−17/13 mm Hg vs. −12/3 mm Hg]; beta-blockers (BBs) [−17/13 mm Hg vs. −12/3 mm Hg] and diuretics [−17/13 mm Hg vs. −3/5 mm Hg]. A statistically significant SBP control was observed in patients treated with long-acting nifedipine in comparison to other major anti-hypertensive drugs (P = 0.0085). In our analysis, BBs were associated with highest number of adverse events (75.3 ± 8.68), followed by long-acting nifedipine (61 ± 7.81), ACEIs (34.7 ± 5.89) and diuretics (19.5 ± 4.42). Conclusion: Long-acting nifedipine exhibited a promising clinical outcome with higher efficacy in reducing the BP and almost similar safety profile in comparison to other major anti-hypertensive drugs. The findings of our study may act as a guide for the clinicians prescribing individualised anti-hypertensive regimen." @default.
- W2899461507 created "2018-11-09" @default.
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- W2899461507 date "2018-10-01" @default.
- W2899461507 modified "2023-09-27" @default.
- W2899461507 title "A1542 Role of long-acting nifedipine in the management of hypertension" @default.
- W2899461507 doi "https://doi.org/10.1097/01.hjh.0000548492.26435.56" @default.
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