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• W2899469574 abstract "Objective Carbon-11-(11C)-choline PET/computed tomography (CT) has shown good results in re-staging of prostate cancer (PCa) with raised serum levels of prostate-specific antigen. Our aim was to evaluate the effect of positive 11C-choline PET/CT results in the therapeutic management of patients with PCa with biochemical relapse (BR) after curative intention treatment. Patients and methods A total of 112 patients with PCa BR and positive 11C-choline PET/CT were retrospectively evaluated. PET/CT was acquired 20 min after intravenous administration of 555–740 MBq of 11C-choline. The therapeutic management after 11C-choline PET/CT was obtained from the clinical records. The minimum follow-up time was 18 months. Results In 80 (71.4%) of 112 patients, 11C-choline PET/CT showed local recurrence of PCa; in 17 (15.2%) patients, distant recurrence; and in 15 (13.4%) patients, local plus distant recurrence. A second malignancy was detected in five (4.5%) patients. The planned therapeutic management was changed as per positive 11C-choline PET/CT result in 74 (66.1%) patients and were treated as follows: 31 (27.7%) patients with HT, combined with other treatments in eight (7.1%), 17 (15.2%) with BT, 13 (11.6%) with external beam radiotherapy, one (0.9%) with RP, and four (3.6%) with chemotherapy. Treatment approach was not modified in 37 (33%) patients. No data was available from one (0.9%) patient. Conclusion Positive 11C-choline PET/CT result had an important effect in the therapeutic management of patients with PCa and BR, leading to a change in the planned approach in two (66.1%) out of three patients. In addition, in 4.5% of the patients, the 11C-choline PET/CT allowed the detection of a second malignancy." @default.
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• W2899469574 date "2019-01-01" @default.
• W2899469574 modified "2023-10-16" @default.
• W2899469574 title "Effect of positive carbon-11-choline PET/CT results in the therapeutic management of prostate cancer biochemical relapse" @default.
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• W2899469574 doi "https://doi.org/10.1097/mnm.0000000000000936" @default.
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