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• W2899475979 abstract "Abstract There have been several recent comprehensive reviews of gastroesophageal reflux (GER) and gastroesophageal reflux disease (GERD) in neonates that include evidence-based recommendations for treatment. Nevertheless, it likely comes as no surprise to neonatologists to learn that this topic still engenders much debate. Neonatologists are often especially challenged by the question of how to best diagnose reflux disorders, in addition to how to best manage them using an evidence basis, in both term and preterm newborns. This is because infants may be particularly vulnerable to risks from complications of invasive testing to characterize and document reflux, including pH/impedance testing and endoscopy. Fortunately, most neonates with GER and GERD can be diagnosed clinically and require no diagnostic testing or consultation. Furthermore, lifestyle approaches, including dietary changes, are almost always recommended as first-line management approaches to both. When conservative, nonmedication measures are not successful or when associated complications of reflux are evident, it may be appropriate to consider a stepwise approach to acid suppression therapy, often starting with H2-receptor antagonists and escalating to proton-pump inhibitors if symptoms do not improve. However, recent reports of a strong relationship between acid suppression and hospital-acquired infections increasingly belong in a risk–benefit discussion around clinical decision making. Indeed, with no clear evidence of efficacy and increasing concern for side effects of their use, pharmacologic agents in neonates should likely only be used with caution and with an up-to-date understanding of best evidence for both." @default.
• W2899475979 created "2018-11-09" @default.
• W2899475979 creator A5053861201 @default.
• W2899475979 creator A5082039225 @default.
• W2899475979 date "2019-01-01" @default.
• W2899475979 modified "2023-09-25" @default.
• W2899475979 title "Therapies for Gastroesophageal Reflux in Infants" @default.
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• W2899475979 doi "https://doi.org/10.1016/b978-0-323-54391-0.00020-5" @default.
• W2899475979 hasPublicationYear "2019" @default.
• W2899475979 type Work @default.

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