FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899488296> ?p ?o ?g. }

• W2899488296 endingPage "1623" @default.
• W2899488296 startingPage "1623" @default.
• W2899488296 abstract "Elevated blood free fatty acids (FFAs), as seen in obesity, impair muscle insulin action leading to insulin resistance and Type 2 diabetes mellitus. Serine phosphorylation of the insulin receptor substrate (IRS) is linked to insulin resistance and a number of serine/threonine kinases including JNK, mTOR and p70 S6K have been implicated in this process. Activation of the energy sensor AMP-activated protein kinase (AMPK) increases muscle glucose uptake, and in recent years AMPK has been viewed as an important target to counteract insulin resistance. We reported recently that rosemary extract (RE) increased muscle cell glucose uptake and activated AMPK. However, the effect of RE on FFA-induced muscle insulin resistance has never been examined. In the current study, we investigated the effect of RE in palmitate-induced insulin resistant L6 myotubes. Exposure of myotubes to palmitate reduced the insulin-stimulated glucose uptake, increased serine phosphorylation of IRS-1, and decreased the insulin-stimulated phosphorylation of Akt. Importantly, exposure to RE abolished these effects and the insulin-stimulated glucose uptake was restored. Treatment with palmitate increased the phosphorylation/activation of JNK, mTOR and p70 S6K whereas RE completely abolished these effects. RE increased the phosphorylation of AMPK even in the presence of palmitate. Our data indicate that rosemary extract has the potential to counteract the palmitate-induced muscle cell insulin resistance and further studies are required to explore its antidiabetic properties." @default.
• W2899488296 created "2018-11-09" @default.
• W2899488296 creator A5039182946 @default.
• W2899488296 creator A5084524833 @default.
• W2899488296 date "2018-11-02" @default.
• W2899488296 modified "2023-10-16" @default.
• W2899488296 title "Attenuation of Free Fatty Acid-Induced Muscle Insulin Resistance by Rosemary Extract" @default.
• W2899488296 cites W1272736325 @default.
• W2899488296 cites W1523693806 @default.
• W2899488296 cites W1908152908 @default.
• W2899488296 cites W1965102835 @default.
• W2899488296 cites W1967737207 @default.
• W2899488296 cites W1970300247 @default.
• W2899488296 cites W1970306975 @default.
• W2899488296 cites W1972202513 @default.
• W2899488296 cites W1975299036 @default.
• W2899488296 cites W1982563578 @default.
• W2899488296 cites W1983890824 @default.
• W2899488296 cites W1984601608 @default.
• W2899488296 cites W1984621921 @default.
• W2899488296 cites W1988848089 @default.
• W2899488296 cites W1990795325 @default.
• W2899488296 cites W1998493448 @default.
• W2899488296 cites W2011818278 @default.
• W2899488296 cites W2016752484 @default.
• W2899488296 cites W2017010150 @default.
• W2899488296 cites W2022221591 @default.
• W2899488296 cites W2023599093 @default.
• W2899488296 cites W2025391287 @default.
• W2899488296 cites W2030467598 @default.
• W2899488296 cites W2031840166 @default.
• W2899488296 cites W2038018821 @default.
• W2899488296 cites W2045164631 @default.
• W2899488296 cites W2046946656 @default.
• W2899488296 cites W2049225751 @default.
• W2899488296 cites W2052944703 @default.
• W2899488296 cites W2054760917 @default.
• W2899488296 cites W2060817524 @default.
• W2899488296 cites W2064602675 @default.
• W2899488296 cites W2067096633 @default.
• W2899488296 cites W2067156757 @default.
• W2899488296 cites W2067872036 @default.
• W2899488296 cites W2068565795 @default.
• W2899488296 cites W2073959976 @default.
• W2899488296 cites W2079580613 @default.
• W2899488296 cites W2082205399 @default.
• W2899488296 cites W2084521532 @default.
• W2899488296 cites W2087962053 @default.
• W2899488296 cites W2089230624 @default.
• W2899488296 cites W2090590228 @default.
• W2899488296 cites W2105244824 @default.
• W2899488296 cites W2107674876 @default.
• W2899488296 cites W2107722417 @default.
• W2899488296 cites W2110677712 @default.
• W2899488296 cites W2110779759 @default.
• W2899488296 cites W2111645882 @default.
• W2899488296 cites W2115435380 @default.
• W2899488296 cites W2119101865 @default.
• W2899488296 cites W2119501626 @default.
• W2899488296 cites W2129099714 @default.
• W2899488296 cites W2130850001 @default.
• W2899488296 cites W2131210334 @default.
• W2899488296 cites W2138226825 @default.
• W2899488296 cites W2138446733 @default.
• W2899488296 cites W2154883306 @default.
• W2899488296 cites W2159158942 @default.
• W2899488296 cites W2159664830 @default.
• W2899488296 cites W2160524748 @default.
• W2899488296 cites W2160615487 @default.
• W2899488296 cites W2167349873 @default.
• W2899488296 cites W2192080449 @default.
• W2899488296 cites W2344401472 @default.
• W2899488296 cites W2407752024 @default.
• W2899488296 cites W2412476010 @default.
• W2899488296 cites W2469968941 @default.
• W2899488296 cites W2523476210 @default.
• W2899488296 cites W2531701661 @default.
• W2899488296 cites W2551193853 @default.
• W2899488296 cites W2558779362 @default.
• W2899488296 cites W2570314532 @default.
• W2899488296 cites W2607648378 @default.
• W2899488296 cites W2751672023 @default.
• W2899488296 cites W2761065488 @default.
• W2899488296 cites W2800229438 @default.
• W2899488296 cites W425890144 @default.
• W2899488296 doi "https://doi.org/10.3390/nu10111623" @default.
• W2899488296 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6267446" @default.
• W2899488296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30400151" @default.
• W2899488296 hasPublicationYear "2018" @default.
• W2899488296 type Work @default.
• W2899488296 sameAs 2899488296 @default.
• W2899488296 citedByCount "21" @default.
• W2899488296 countsByYear W28994882962019 @default.
• W2899488296 countsByYear W28994882962020 @default.
• W2899488296 countsByYear W28994882962021 @default.
• W2899488296 countsByYear W28994882962022 @default.
• W2899488296 countsByYear W28994882962023 @default.
• W2899488296 crossrefType "journal-article" @default.

• next