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• W2899492053 abstract "Background: Growing evidence shows that impaired signaling of Insulin-like Growth Factor-1 (IGF-1) is associated with neurodegenerative disorders, such as Parkinson's disease (PD). However, there is still controversy regarding its proinflammatory or neuroprotective function. In an attempt to elucidate the contribution of IGF-1 in PD, we aimed to discover the relation between serum IGF-1 levels in drug-naïve early PD patients and cerebrospinal fluid (CSF) biomarkers as well as microstructural changes in brain white matter. Methods: The association between quartiles of serum IGF-1 levels and CSF biomarkers (α-synuclein, dopamine, amyloid-β1-42, total tau, and phosphorylated tau) was investigated using adjusted regression models in 404 drug-naïve early PD patients with only mild motor manifestations and 188 age- and sex-matched healthy controls (HC) enrolled in the Parkinson's Progression Markers Initiative (PPMI). By using region of interest analysis and connectometry approach, we tracked the white matter microstructural integrity and diffusivity patterns in a subgroup of study participants with available diffusion MRI data to investigate the association between subcomponents of neural pathways with serum IGF-1 levels. Results: PD patients had higher levels of IGF-1 compared to HC, although not statistically significant (mean difference: 3.60, P = 0.44). However, after adjustment for possible confounders and correction for False Discovery Rate (FDR), IGF-1 was negatively correlated with CSF α-synuclein, total and phosphorylated tau levels only in PD subjects. The imaging analysis proved a significant negative correlation (FDR corrected P-value = 0.013) between continuous levels of serum IGF-1 in patients with PD and the connectivity, but not integrity, in following fibers while controlling for age, sex, body mass index, depressive symptoms, education years, cognitive status and disease duration: middle cerebellar peduncle, cingulum, genu and splenium of the corpus callosum. No significant association was found between brain white matter microstructral measures or CSF markers of healthy controls and levels of IGF-1. Conclusion: Altered connectivity in specific white matter structures, mainly involved in cognitive and motor deterioration, in association with higher serum IGF-1 levels might propose IGF-1 as a potential associate of worse outcome in response to higher burden of α-synucleinopathy and tauopathy in PD." @default.
• W2899492053 created "2018-11-09" @default.
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• W2899492053 date "2018-11-02" @default.
• W2899492053 modified "2023-09-23" @default.
• W2899492053 title "Serum Insulin-Like Growth Factor-1 in Parkinson's Disease; Study of Cerebrospinal Fluid Biomarkers and White Matter Microstructure" @default.
• W2899492053 cites W1950995754 @default.
• W2899492053 cites W1966169278 @default.
• W2899492053 cites W1966569650 @default.
• W2899492053 cites W1968942251 @default.
• W2899492053 cites W1969597891 @default.
• W2899492053 cites W1979137641 @default.
• W2899492053 cites W1987003014 @default.
• W2899492053 cites W1991073726 @default.
• W2899492053 cites W1997738406 @default.
• W2899492053 cites W2001361641 @default.
• W2899492053 cites W2001943859 @default.
• W2899492053 cites W2005809856 @default.
• W2899492053 cites W2006140418 @default.
• W2899492053 cites W2009036027 @default.
• W2899492053 cites W2012756230 @default.
• W2899492053 cites W2020183671 @default.
• W2899492053 cites W2025007739 @default.
• W2899492053 cites W2025805353 @default.
• W2899492053 cites W2028133242 @default.
• W2899492053 cites W2029085167 @default.
• W2899492053 cites W2029164422 @default.
• W2899492053 cites W2031472414 @default.
• W2899492053 cites W2032807094 @default.
• W2899492053 cites W2034169931 @default.
• W2899492053 cites W2034340557 @default.
• W2899492053 cites W2040042139 @default.
• W2899492053 cites W2040705927 @default.
• W2899492053 cites W2041635321 @default.
• W2899492053 cites W2046668712 @default.
• W2899492053 cites W2054620054 @default.
• W2899492053 cites W2055097813 @default.
• W2899492053 cites W2057286215 @default.
• W2899492053 cites W2063254939 @default.
• W2899492053 cites W2064963539 @default.
• W2899492053 cites W2066118053 @default.
• W2899492053 cites W2067443877 @default.
• W2899492053 cites W2072735944 @default.
• W2899492053 cites W2079878023 @default.
• W2899492053 cites W2080077305 @default.
• W2899492053 cites W2092505220 @default.
• W2899492053 cites W2100686676 @default.
• W2899492053 cites W2105035648 @default.
• W2899492053 cites W2115614582 @default.
• W2899492053 cites W2117786663 @default.
• W2899492053 cites W2118339728 @default.
• W2899492053 cites W2119442234 @default.
• W2899492053 cites W2131307089 @default.
• W2899492053 cites W2131881760 @default.
• W2899492053 cites W2134113727 @default.
• W2899492053 cites W2137918406 @default.
• W2899492053 cites W2143386195 @default.
• W2899492053 cites W2151854373 @default.
• W2899492053 cites W2152338753 @default.
• W2899492053 cites W2160412284 @default.
• W2899492053 cites W2164028779 @default.
• W2899492053 cites W2181004835 @default.
• W2899492053 cites W2299286270 @default.
• W2899492053 cites W2323845838 @default.
• W2899492053 cites W2323935001 @default.
• W2899492053 cites W2330640534 @default.
• W2899492053 cites W2337902758 @default.
• W2899492053 cites W2400155502 @default.
• W2899492053 cites W2417724549 @default.
• W2899492053 cites W2525795464 @default.
• W2899492053 cites W2528242093 @default.
• W2899492053 cites W2539957110 @default.
• W2899492053 cites W2559739875 @default.
• W2899492053 cites W2765142134 @default.
• W2899492053 cites W2766652339 @default.
• W2899492053 cites W2767078245 @default.
• W2899492053 cites W2767236431 @default.
• W2899492053 cites W2770565967 @default.
• W2899492053 cites W2792008767 @default.
• W2899492053 cites W2796272698 @default.
• W2899492053 cites W2804164821 @default.
• W2899492053 cites W2810593917 @default.
• W2899492053 cites W2811228280 @default.
• W2899492053 cites W2823503902 @default.
• W2899492053 cites W2886698364 @default.
• W2899492053 cites W2952495854 @default.
• W2899492053 cites W2952835181 @default.
• W2899492053 doi "https://doi.org/10.3389/fendo.2018.00608" @default.
• W2899492053 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6224341" @default.
• W2899492053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30450079" @default.
• W2899492053 hasPublicationYear "2018" @default.
• W2899492053 type Work @default.
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