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- W2899500579 abstract "Many traditional approaches for solving the chemical master equation (CME) cannot be used in their basic form when reaction rates change over time, for instance due to cell volume or temperature. One technique is to use the Magnus expansion to represent the solution to the CME as the action of a matrix exponential, for which Krylov-based approximation methods can be applied. In this paper, we compare two variants of the Magnus scheme with some popular ordinary differential equations (ODE) solvers, such as Adams-Bashforth, Runge-Kutta and Backward-differentiation formula (BDF). Our numerical tests show that the Magnus variants are remarkably efficient at computing the transient probability distributions of a transcriptional regulatory system where propensities vary over time due to cell volume increase." @default.
- W2899500579 created "2018-11-09" @default.
- W2899500579 creator A5051254917 @default.
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- W2899500579 date "2018-01-01" @default.
- W2899500579 modified "2023-09-27" @default.
- W2899500579 title "A Comparison of the Magnus Expansion and Other Solvers for the Chemical Master Equation with Variable Rates" @default.
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- W2899500579 doi "https://doi.org/10.1007/978-3-319-99719-3_24" @default.
- W2899500579 hasPublicationYear "2018" @default.
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