FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899503076> ?p ?o ?g. }

• W2899503076 abstract "Lamin A and lamin C isoforms of the gene LMNA are major structural and mechanotransductive components of the nuclear lamina. Previous reports have proposed lamin A as the isoform with the most dominant contributions to cellular mechanophenotype. Recently, expression of lamin C has also been shown to strongly correlate to cellular elastic and viscoelastic properties. Nevertheless, LMNA isoforms exist as part of a network that collectively provides structural integrity to the nucleus and their expression is ultimately regulated in a cell-specific manner. Thus, they have importance in mechanotransduction and structural integrity of the nucleus as well as potential candidates for biomarkers of whole-cell mechanophenotype. Therefore, a fuller discussion of lamin isoforms as mechanophenotypic biomarkers should compare both individual and ratiometric isoform contributions towards whole-cell mechanophenotype across different cell types. In this perspective, we discuss the distinctions between the mechanophenotypic correlations of individual and ratiometric lamins A:B1, C:B1, (A+C):B1, and C:A across cells from different lineages, demonstrating that the collective contribution of ratiometric lamin (A+C):B1 isoforms exhibited the strongest correlation to whole-cell stiffness. Additionally, we highlight the potential roles of lamin isoform ratios as indicators of mechanophenotypic change in differentiation and disease to demonstrate that the contributions of individual and collective lamin isoforms can occur as both static and dynamic biomarkers of mechanophenotype." @default.
• W2899503076 created "2018-11-09" @default.
• W2899503076 creator A5035365842 @default.
• W2899503076 creator A5053646968 @default.
• W2899503076 creator A5085642676 @default.
• W2899503076 date "2018-11-02" @default.
• W2899503076 modified "2023-09-26" @default.
• W2899503076 title "The Emerging Role of Lamin C as an Important LMNA Isoform in Mechanophenotype" @default.
• W2899503076 cites W1517701294 @default.
• W2899503076 cites W1665551917 @default.
• W2899503076 cites W1840755223 @default.
• W2899503076 cites W1970338621 @default.
• W2899503076 cites W1983533553 @default.
• W2899503076 cites W2004268823 @default.
• W2899503076 cites W2016795617 @default.
• W2899503076 cites W2030637965 @default.
• W2899503076 cites W2033912008 @default.
• W2899503076 cites W2035838778 @default.
• W2899503076 cites W2037999013 @default.
• W2899503076 cites W2041599232 @default.
• W2899503076 cites W2049487472 @default.
• W2899503076 cites W2052373675 @default.
• W2899503076 cites W2052612687 @default.
• W2899503076 cites W2056727159 @default.
• W2899503076 cites W2057025275 @default.
• W2899503076 cites W2057329292 @default.
• W2899503076 cites W2064005074 @default.
• W2899503076 cites W2083406872 @default.
• W2899503076 cites W2101083045 @default.
• W2899503076 cites W2117633469 @default.
• W2899503076 cites W2120207407 @default.
• W2899503076 cites W2122131642 @default.
• W2899503076 cites W2122867798 @default.
• W2899503076 cites W2127394968 @default.
• W2899503076 cites W2127659175 @default.
• W2899503076 cites W2127708563 @default.
• W2899503076 cites W2132917470 @default.
• W2899503076 cites W2135568518 @default.
• W2899503076 cites W2141365953 @default.
• W2899503076 cites W2143185290 @default.
• W2899503076 cites W2157478214 @default.
• W2899503076 cites W2160224424 @default.
• W2899503076 cites W2161800491 @default.
• W2899503076 cites W2165134887 @default.
• W2899503076 cites W2167200020 @default.
• W2899503076 cites W2172002964 @default.
• W2899503076 cites W2188508288 @default.
• W2899503076 cites W2227469241 @default.
• W2899503076 cites W2287005707 @default.
• W2899503076 cites W2311161794 @default.
• W2899503076 cites W2558236976 @default.
• W2899503076 cites W2733597369 @default.
• W2899503076 cites W2752435367 @default.
• W2899503076 cites W2772204201 @default.
• W2899503076 cites W2783874796 @default.
• W2899503076 cites W2795448108 @default.
• W2899503076 cites W2797549363 @default.
• W2899503076 cites W2804142965 @default.
• W2899503076 cites W4211059758 @default.
• W2899503076 cites W4247425028 @default.
• W2899503076 doi "https://doi.org/10.3389/fcell.2018.00151" @default.
• W2899503076 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6224339" @default.
• W2899503076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30450357" @default.
• W2899503076 hasPublicationYear "2018" @default.
• W2899503076 type Work @default.
• W2899503076 sameAs 2899503076 @default.
• W2899503076 citedByCount "20" @default.
• W2899503076 countsByYear W28995030762019 @default.
• W2899503076 countsByYear W28995030762020 @default.
• W2899503076 countsByYear W28995030762021 @default.
• W2899503076 countsByYear W28995030762022 @default.
• W2899503076 countsByYear W28995030762023 @default.
• W2899503076 crossrefType "journal-article" @default.
• W2899503076 hasAuthorship W2899503076A5035365842 @default.
• W2899503076 hasAuthorship W2899503076A5053646968 @default.
• W2899503076 hasAuthorship W2899503076A5085642676 @default.
• W2899503076 hasBestOaLocation W28995030761 @default.
• W2899503076 hasConcept C104317684 @default.
• W2899503076 hasConcept C179093185 @default.
• W2899503076 hasConcept C181104049 @default.
• W2899503076 hasConcept C2780654407 @default.
• W2899503076 hasConcept C2780723820 @default.
• W2899503076 hasConcept C29512474 @default.
• W2899503076 hasConcept C53345823 @default.
• W2899503076 hasConcept C54355233 @default.
• W2899503076 hasConcept C86339819 @default.
• W2899503076 hasConcept C86803240 @default.
• W2899503076 hasConcept C94912109 @default.
• W2899503076 hasConcept C95444343 @default.
• W2899503076 hasConceptScore W2899503076C104317684 @default.
• W2899503076 hasConceptScore W2899503076C179093185 @default.
• W2899503076 hasConceptScore W2899503076C181104049 @default.
• W2899503076 hasConceptScore W2899503076C2780654407 @default.
• W2899503076 hasConceptScore W2899503076C2780723820 @default.
• W2899503076 hasConceptScore W2899503076C29512474 @default.
• W2899503076 hasConceptScore W2899503076C53345823 @default.
• W2899503076 hasConceptScore W2899503076C54355233 @default.
• W2899503076 hasConceptScore W2899503076C86339819 @default.
• W2899503076 hasConceptScore W2899503076C86803240 @default.
• W2899503076 hasConceptScore W2899503076C94912109 @default.

• next