Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899529410> ?p ?o ?g. }
- W2899529410 endingPage "387.e4" @default.
- W2899529410 startingPage "377" @default.
- W2899529410 abstract "Embryos have a striking ability to heal wounds rapidly and without scarring. Embryonic wound repair is a conserved process, driven by polarization of cell-cell junctions and the actomyosin cytoskeleton in the cells around the wound. However, the upstream signals that trigger cell polarization around wounds are unknown. We used quantitative in vivo microscopy in Drosophila and zebrafish embryos to identify reactive oxygen species (ROS) as a critical signal that orchestrates cell polarity around wounds. ROS promote trafficking of adherens junctions and accumulation of actin and myosin at the wound edge and are necessary for wound closure. We show that, in Drosophila, ROS drive wound healing in part through an ortholog of Src kinase, Src42A, which we identify as a redox sensor that promotes polarization of junctions and the cytoskeleton around wounds. We propose that ROS are a reparative signal that drives rapid embryonic wound healing in vertebrate and invertebrate species." @default.
- W2899529410 created "2018-11-16" @default.
- W2899529410 creator A5002127292 @default.
- W2899529410 creator A5003732636 @default.
- W2899529410 creator A5023497605 @default.
- W2899529410 creator A5078934880 @default.
- W2899529410 date "2018-11-01" @default.
- W2899529410 modified "2023-10-18" @default.
- W2899529410 title "Oxidative Stress Orchestrates Cell Polarity to Promote Embryonic Wound Healing" @default.
- W2899529410 cites W1479970844 @default.
- W2899529410 cites W1781095925 @default.
- W2899529410 cites W1911021731 @default.
- W2899529410 cites W1934775191 @default.
- W2899529410 cites W1974210089 @default.
- W2899529410 cites W1976484714 @default.
- W2899529410 cites W1977828367 @default.
- W2899529410 cites W1980040451 @default.
- W2899529410 cites W1981566818 @default.
- W2899529410 cites W1987817703 @default.
- W2899529410 cites W1989987141 @default.
- W2899529410 cites W1992740290 @default.
- W2899529410 cites W1994042842 @default.
- W2899529410 cites W1995984781 @default.
- W2899529410 cites W2002356275 @default.
- W2899529410 cites W2004303921 @default.
- W2899529410 cites W2007361012 @default.
- W2899529410 cites W2009314584 @default.
- W2899529410 cites W2010805937 @default.
- W2899529410 cites W2013557200 @default.
- W2899529410 cites W2021014465 @default.
- W2899529410 cites W2025654941 @default.
- W2899529410 cites W2037871836 @default.
- W2899529410 cites W2039372797 @default.
- W2899529410 cites W2043155515 @default.
- W2899529410 cites W2052973245 @default.
- W2899529410 cites W2058397178 @default.
- W2899529410 cites W2069398477 @default.
- W2899529410 cites W2069463594 @default.
- W2899529410 cites W2073006837 @default.
- W2899529410 cites W2074561761 @default.
- W2899529410 cites W2087238801 @default.
- W2899529410 cites W2090253817 @default.
- W2899529410 cites W2090895449 @default.
- W2899529410 cites W2093858064 @default.
- W2899529410 cites W2094735120 @default.
- W2899529410 cites W2096533016 @default.
- W2899529410 cites W2101281572 @default.
- W2899529410 cites W2104005887 @default.
- W2899529410 cites W2119162687 @default.
- W2899529410 cites W2125349610 @default.
- W2899529410 cites W2131179754 @default.
- W2899529410 cites W2136386024 @default.
- W2899529410 cites W2142453339 @default.
- W2899529410 cites W2142976942 @default.
- W2899529410 cites W2155255760 @default.
- W2899529410 cites W2156552281 @default.
- W2899529410 cites W2156975736 @default.
- W2899529410 cites W2161007406 @default.
- W2899529410 cites W2161742793 @default.
- W2899529410 cites W2166394159 @default.
- W2899529410 cites W2166499489 @default.
- W2899529410 cites W2254380769 @default.
- W2899529410 cites W2265466745 @default.
- W2899529410 cites W2414709063 @default.
- W2899529410 cites W2508180552 @default.
- W2899529410 cites W2587928993 @default.
- W2899529410 cites W2801043232 @default.
- W2899529410 cites W4250785114 @default.
- W2899529410 doi "https://doi.org/10.1016/j.devcel.2018.10.013" @default.
- W2899529410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30399336" @default.
- W2899529410 hasPublicationYear "2018" @default.
- W2899529410 type Work @default.
- W2899529410 sameAs 2899529410 @default.
- W2899529410 citedByCount "49" @default.
- W2899529410 countsByYear W28995294102019 @default.
- W2899529410 countsByYear W28995294102020 @default.
- W2899529410 countsByYear W28995294102021 @default.
- W2899529410 countsByYear W28995294102022 @default.
- W2899529410 countsByYear W28995294102023 @default.
- W2899529410 crossrefType "journal-article" @default.
- W2899529410 hasAuthorship W2899529410A5002127292 @default.
- W2899529410 hasAuthorship W2899529410A5003732636 @default.
- W2899529410 hasAuthorship W2899529410A5023497605 @default.
- W2899529410 hasAuthorship W2899529410A5078934880 @default.
- W2899529410 hasBestOaLocation W28995294101 @default.
- W2899529410 hasConcept C104317684 @default.
- W2899529410 hasConcept C125705527 @default.
- W2899529410 hasConcept C137738243 @default.
- W2899529410 hasConcept C142669718 @default.
- W2899529410 hasConcept C145103041 @default.
- W2899529410 hasConcept C1491633281 @default.
- W2899529410 hasConcept C149402561 @default.
- W2899529410 hasConcept C201508349 @default.
- W2899529410 hasConcept C203014093 @default.
- W2899529410 hasConcept C2776878037 @default.
- W2899529410 hasConcept C2780269544 @default.
- W2899529410 hasConcept C2993400109 @default.
- W2899529410 hasConcept C48349386 @default.