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- W2899532948 abstract "Mood disorders, including major depression, bipolar disorder, and seasonal affective disorder, are debilitating disorders that affect a significant portion of the global population. Individuals suffering from mood disorders often show significant disturbances in circadian rhythms and sleep. Moreover, environmental disruptions to circadian rhythms can precipitate or exacerbate mood symptoms in vulnerable individuals. Circadian clocks exist throughout the central nervous system and periphery, where they regulate a wide variety of physiological processes implicated in mood regulation. These processes include monoaminergic and glutamatergic transmission, hypothalamic-pituitary-adrenal axis function, metabolism, and immune function. While there seems to be a clear link between circadian rhythm disruption and mood regulation, the mechanisms that underlie this association remain unclear. This review will touch on the interactions between the circadian system and each of these processes and discuss their potential role in the development of mood disorders. While clinical studies are presented, much of the review will focus on studies in animal models, which are attempting to elucidate the molecular and cellular mechanisms in which circadian genes regulate mood." @default.
- W2899532948 created "2018-11-16" @default.
- W2899532948 creator A5017300902 @default.
- W2899532948 creator A5029888437 @default.
- W2899532948 creator A5077847471 @default.
- W2899532948 date "2018-11-29" @default.
- W2899532948 modified "2023-10-16" @default.
- W2899532948 title "Mood‐related central and peripheral clocks" @default.
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