Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899545963> ?p ?o ?g. }
- W2899545963 endingPage "591" @default.
- W2899545963 startingPage "580" @default.
- W2899545963 abstract "Transforming growth factor beta (TGFβ) is multifunctional cytokine that is involved in the coordination and regulation of many cellular homeostatic processes. Compromised TGFβ activity has been attributed to promotion of human cancers. Recent studies have identified a role for TGFβ in response to radiation-induced DNA damage, suggesting a link between TGFβ and the DNA damage response with implications for cancer development. In this study, the effects of TGFβ on promoting the repair of bulky DNA damage, through modulation of nucleotide excision repair (NER), were investigated. We show that treatment of cells with exogenous TGFβ leads to enhanced repair of DNA damage formed by polycyclic aromatic hydrocarbons and ultraviolet-C radiation; similarly, cells with constitutively activated endogenous TGFβ signaling show comparable responses. This effect of TGFβ is independent of the cell cycle. The response to TGFβ is decreased in cells that have compromised TGFβ signaling through RNA interference of Smad4 and is decreased in NER-deficient cells and cells with compromised NER through RNA interference of excision repair cross-complementing group 1 (ERCC1). Increased interaction and nuclear localization of ERCC1/xeroderma pigmentosum (XP) F and ERCC1/XPA proteins is observed after TGFβ treatment. Our study represents the first experimental evidence of a role for TGFβ in the repair of bulky DNA damage resulting from promotion of the interaction and localization of repair protein complexes involved in the incision step of NER." @default.
- W2899545963 created "2018-11-16" @default.
- W2899545963 creator A5002198650 @default.
- W2899545963 creator A5005196808 @default.
- W2899545963 creator A5036940014 @default.
- W2899545963 creator A5040725679 @default.
- W2899545963 creator A5062707573 @default.
- W2899545963 date "2018-11-12" @default.
- W2899545963 modified "2023-10-02" @default.
- W2899545963 title "TGF beta promotes repair of bulky DNA damage through increased ERCC1/XPF and ERCC1/XPA interaction" @default.
- W2899545963 cites W1515564094 @default.
- W2899545963 cites W1588173849 @default.
- W2899545963 cites W1663371441 @default.
- W2899545963 cites W1970098795 @default.
- W2899545963 cites W1973355845 @default.
- W2899545963 cites W1975976826 @default.
- W2899545963 cites W1984466608 @default.
- W2899545963 cites W1985775217 @default.
- W2899545963 cites W1986761127 @default.
- W2899545963 cites W1998612778 @default.
- W2899545963 cites W2010677667 @default.
- W2899545963 cites W2022215384 @default.
- W2899545963 cites W2023620387 @default.
- W2899545963 cites W2026743476 @default.
- W2899545963 cites W2030016898 @default.
- W2899545963 cites W2037038224 @default.
- W2899545963 cites W2037714522 @default.
- W2899545963 cites W2045867556 @default.
- W2899545963 cites W2051493175 @default.
- W2899545963 cites W2057794734 @default.
- W2899545963 cites W2073155860 @default.
- W2899545963 cites W2074044723 @default.
- W2899545963 cites W2084369408 @default.
- W2899545963 cites W2084969545 @default.
- W2899545963 cites W2095605427 @default.
- W2899545963 cites W2097829282 @default.
- W2899545963 cites W2102752109 @default.
- W2899545963 cites W2107554012 @default.
- W2899545963 cites W2109816131 @default.
- W2899545963 cites W2117538896 @default.
- W2899545963 cites W2121126525 @default.
- W2899545963 cites W2124227044 @default.
- W2899545963 cites W2128329009 @default.
- W2899545963 cites W2131936396 @default.
- W2899545963 cites W2134690686 @default.
- W2899545963 cites W2139021684 @default.
- W2899545963 cites W2142341469 @default.
- W2899545963 cites W2146995890 @default.
- W2899545963 cites W2148434747 @default.
- W2899545963 cites W2163885210 @default.
- W2899545963 cites W2164672043 @default.
- W2899545963 cites W2166424758 @default.
- W2899545963 cites W2265470861 @default.
- W2899545963 cites W2316067769 @default.
- W2899545963 cites W2547904659 @default.
- W2899545963 doi "https://doi.org/10.1093/carcin/bgy156" @default.
- W2899545963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30418489" @default.
- W2899545963 hasPublicationYear "2018" @default.
- W2899545963 type Work @default.
- W2899545963 sameAs 2899545963 @default.
- W2899545963 citedByCount "16" @default.
- W2899545963 countsByYear W28995459632019 @default.
- W2899545963 countsByYear W28995459632020 @default.
- W2899545963 countsByYear W28995459632021 @default.
- W2899545963 countsByYear W28995459632022 @default.
- W2899545963 countsByYear W28995459632023 @default.
- W2899545963 crossrefType "journal-article" @default.
- W2899545963 hasAuthorship W2899545963A5002198650 @default.
- W2899545963 hasAuthorship W2899545963A5005196808 @default.
- W2899545963 hasAuthorship W2899545963A5036940014 @default.
- W2899545963 hasAuthorship W2899545963A5040725679 @default.
- W2899545963 hasAuthorship W2899545963A5062707573 @default.
- W2899545963 hasConcept C104451858 @default.
- W2899545963 hasConcept C134935766 @default.
- W2899545963 hasConcept C143425029 @default.
- W2899545963 hasConcept C185592680 @default.
- W2899545963 hasConcept C2778378917 @default.
- W2899545963 hasConcept C2779309665 @default.
- W2899545963 hasConcept C502942594 @default.
- W2899545963 hasConcept C54355233 @default.
- W2899545963 hasConcept C552990157 @default.
- W2899545963 hasConcept C86803240 @default.
- W2899545963 hasConcept C95444343 @default.
- W2899545963 hasConceptScore W2899545963C104451858 @default.
- W2899545963 hasConceptScore W2899545963C134935766 @default.
- W2899545963 hasConceptScore W2899545963C143425029 @default.
- W2899545963 hasConceptScore W2899545963C185592680 @default.
- W2899545963 hasConceptScore W2899545963C2778378917 @default.
- W2899545963 hasConceptScore W2899545963C2779309665 @default.
- W2899545963 hasConceptScore W2899545963C502942594 @default.
- W2899545963 hasConceptScore W2899545963C54355233 @default.
- W2899545963 hasConceptScore W2899545963C552990157 @default.
- W2899545963 hasConceptScore W2899545963C86803240 @default.
- W2899545963 hasConceptScore W2899545963C95444343 @default.
- W2899545963 hasFunder F4320321033 @default.
- W2899545963 hasIssue "4" @default.
- W2899545963 hasLocation W28995459631 @default.
- W2899545963 hasLocation W28995459632 @default.