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- W2899559118 abstract "Mucosal-associated invariant T (MAIT) cells are characterized by a semi-invariant TCR that recognizes vitamin B metabolite Ags presented by the MHC-related molecule MR1. Their Ag restriction determines a unique developmental lineage, imbuing a tissue-homing, preprimed phenotype with antimicrobial function. A growing body of literature indicates that MR1-restricted T cells are more diverse than the MAIT term implies. Namely, it is increasingly clear that TCR α- and TCR β-chain diversity within the MR1-restricted repertoire provides a potential mechanism of Ag discrimination, and context-dependent functional variation suggests a role for MR1-restricted T cells in diverse physiological settings. In this paper, we summarize MR1-restricted T cell biology, with an emphasis on TCR diversity, Ag discrimination, and functional heterogeneity." @default.
- W2899559118 created "2018-11-16" @default.
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- W2899559118 date "2018-11-05" @default.
- W2899559118 modified "2023-10-11" @default.
- W2899559118 title "The Diverse Family of MR1-Restricted T Cells" @default.
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- W2899559118 doi "https://doi.org/10.4049/jimmunol.1801091" @default.
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