Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899559779> ?p ?o ?g. }
- W2899559779 endingPage "861" @default.
- W2899559779 startingPage "849" @default.
- W2899559779 abstract "Systemic inflammation may impair male fertility, and its underlying mechanisms remain poorly understood. The present study investigates the effect of lipopolysaccharide (LPS)-induced systemic inflammation on the testis and epididymis in mice. Intraperitoneal injection of LPS significantly impaired testicular functions, including testosterone production, spermatogenesis, and blood–testis barrier permeability. The epididymitis characterized by leukocyte infiltration and fibrosis was observed in the cauda epididymis after LPS injection. LPS-induced testicular dysfunction and epididymitis were abolished in tumor necrosis factor alpha (Tnfa) knockout mice. Pomalidomide, a TNFA inhibitor, blocked the detrimental effects of LPS on the testis and epididymis. The results indicate that LPS-induced systemic inflammation impairs male fertility through TNFA production, suggesting that the intervention on TNFA production would be considered for the prevention and treatment of inflammatory impairment of male fertility." @default.
- W2899559779 created "2018-11-16" @default.
- W2899559779 creator A5002681375 @default.
- W2899559779 creator A5014054330 @default.
- W2899559779 creator A5024147390 @default.
- W2899559779 creator A5036070371 @default.
- W2899559779 creator A5043887907 @default.
- W2899559779 creator A5052046758 @default.
- W2899559779 creator A5052596963 @default.
- W2899559779 creator A5078147769 @default.
- W2899559779 creator A5086529957 @default.
- W2899559779 date "2018-11-06" @default.
- W2899559779 modified "2023-10-17" @default.
- W2899559779 title "Lipopolysaccharide-induced testicular dysfunction and epididymitis in mice: a critical role of tumor necrosis factor alpha†" @default.
- W2899559779 cites W1563808745 @default.
- W2899559779 cites W1965671784 @default.
- W2899559779 cites W1968277840 @default.
- W2899559779 cites W1971713664 @default.
- W2899559779 cites W1982027478 @default.
- W2899559779 cites W1987575651 @default.
- W2899559779 cites W1995177852 @default.
- W2899559779 cites W1999509092 @default.
- W2899559779 cites W1999520474 @default.
- W2899559779 cites W2000437991 @default.
- W2899559779 cites W2005900446 @default.
- W2899559779 cites W2015294286 @default.
- W2899559779 cites W2023823849 @default.
- W2899559779 cites W2029804435 @default.
- W2899559779 cites W2036752094 @default.
- W2899559779 cites W2036829144 @default.
- W2899559779 cites W2047096573 @default.
- W2899559779 cites W2053816889 @default.
- W2899559779 cites W2059638656 @default.
- W2899559779 cites W2079122334 @default.
- W2899559779 cites W2084655958 @default.
- W2899559779 cites W2085292935 @default.
- W2899559779 cites W2086037960 @default.
- W2899559779 cites W2087115371 @default.
- W2899559779 cites W2107219745 @default.
- W2899559779 cites W2107277218 @default.
- W2899559779 cites W2107634114 @default.
- W2899559779 cites W2117665832 @default.
- W2899559779 cites W2120212303 @default.
- W2899559779 cites W2131850468 @default.
- W2899559779 cites W2150532596 @default.
- W2899559779 cites W2153748424 @default.
- W2899559779 cites W2160690739 @default.
- W2899559779 cites W2189465872 @default.
- W2899559779 cites W2256609572 @default.
- W2899559779 cites W2395262410 @default.
- W2899559779 cites W2473346509 @default.
- W2899559779 cites W2496171922 @default.
- W2899559779 cites W2766304453 @default.
- W2899559779 cites W2797138717 @default.
- W2899559779 cites W3214706838 @default.
- W2899559779 doi "https://doi.org/10.1093/biolre/ioy235" @default.
- W2899559779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30398566" @default.
- W2899559779 hasPublicationYear "2018" @default.
- W2899559779 type Work @default.
- W2899559779 sameAs 2899559779 @default.
- W2899559779 citedByCount "34" @default.
- W2899559779 countsByYear W28995597792019 @default.
- W2899559779 countsByYear W28995597792020 @default.
- W2899559779 countsByYear W28995597792021 @default.
- W2899559779 countsByYear W28995597792022 @default.
- W2899559779 countsByYear W28995597792023 @default.
- W2899559779 crossrefType "journal-article" @default.
- W2899559779 hasAuthorship W2899559779A5002681375 @default.
- W2899559779 hasAuthorship W2899559779A5014054330 @default.
- W2899559779 hasAuthorship W2899559779A5024147390 @default.
- W2899559779 hasAuthorship W2899559779A5036070371 @default.
- W2899559779 hasAuthorship W2899559779A5043887907 @default.
- W2899559779 hasAuthorship W2899559779A5052046758 @default.
- W2899559779 hasAuthorship W2899559779A5052596963 @default.
- W2899559779 hasAuthorship W2899559779A5078147769 @default.
- W2899559779 hasAuthorship W2899559779A5086529957 @default.
- W2899559779 hasBestOaLocation W28995597791 @default.
- W2899559779 hasConcept C123765429 @default.
- W2899559779 hasConcept C126322002 @default.
- W2899559779 hasConcept C134018914 @default.
- W2899559779 hasConcept C17991360 @default.
- W2899559779 hasConcept C203014093 @default.
- W2899559779 hasConcept C2776252253 @default.
- W2899559779 hasConcept C2776914184 @default.
- W2899559779 hasConcept C2778754761 @default.
- W2899559779 hasConcept C2779066085 @default.
- W2899559779 hasConcept C2781087480 @default.
- W2899559779 hasConcept C2781105225 @default.
- W2899559779 hasConcept C2781254305 @default.
- W2899559779 hasConcept C2781440318 @default.
- W2899559779 hasConcept C54355233 @default.
- W2899559779 hasConcept C59822182 @default.
- W2899559779 hasConcept C71924100 @default.
- W2899559779 hasConcept C86803240 @default.
- W2899559779 hasConceptScore W2899559779C123765429 @default.
- W2899559779 hasConceptScore W2899559779C126322002 @default.
- W2899559779 hasConceptScore W2899559779C134018914 @default.
- W2899559779 hasConceptScore W2899559779C17991360 @default.