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- W2899572786 abstract "Tumor lymphangiogenesis plays a key role in lymph node (LN) metastasis in oral squamous cell carcinoma (OSCC). The purpose of this study was to investigate podoplanin and lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) and their relationship to nodal metastasis and other clinicopathological variables.Podoplanin and LYVE-1 expression of the primary tumor and normal tissue were investigated by means of a quantitative real-time PCR assay and immunohistochemistry in samples from 33 cases of OSCC.The mRNA high expression levels of both genes had a statistically significantly higher rate of LN metastasis (p<0.01) and histological grade (p<0.01 for podoplanin, p<0.05 for LYVE-1). High expression of each gene, as shown by immunohistochemistry, had a statistically significant higher rate of LN metastasis (p<0.01 for podoplanin, p<0.05 for LYVE-1).Podoplanin and LYVE-1 were strongly associated with LN metastasis." @default.
- W2899572786 created "2018-11-16" @default.
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- W2899572786 date "2018-11-01" @default.
- W2899572786 modified "2023-09-24" @default.
- W2899572786 title "Lymphangiogenesis and Lymph Node Metastasis in Oral Squamous Cell Carcinoma" @default.
- W2899572786 doi "https://doi.org/10.21873/anticanres.12968" @default.
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