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- W2899593875 abstract "ABSTRACT Alterations in the neuromuscular system underlie several neuromuscular diseases and play critical roles in the development of sarcopenia, the age-related loss of muscle mass and function. Mammalian Myostatin (MST) and GDF11, members of the TGF-β superfamily of growth factors, are powerful regulators of muscle size in both model organisms and humans. Myoglianin (MYO), the Drosophila homolog of MST and GDF11, is a strong inhibitor of synaptic function and structure at the neuromuscular junction (NMJ), and a negative regulator of body weight and muscle size and function in flies. Here, we identified Plum, a cell surface immunoglobulin homologous to mammalian developmental regulators Protogenin and Nope, as a modulator of MYO function in the larval neuromuscular system. Reduction of Plum specifically in the larval body-wall muscles abolishes the previously demonstrated positive effect of attenuated MYO signalling on both muscle size and neuromuscular junction structure and function, likely by de-sequestrating the remaining MYO. In addition, downregulation of Plum on its own results in decreased synaptic strength and body weight, classifying Plum as a (novel) regulator of neuromuscular function and body (muscle) size. These findings offer new insights into possible regulatory mechanisms behind ageing- and disease-related neuromuscular dysfunctions in humans and identify potential targets for therapeutic interventions." @default.
- W2899593875 created "2018-11-16" @default.
- W2899593875 creator A5003046646 @default.
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- W2899593875 creator A5067643679 @default.
- W2899593875 date "2018-11-06" @default.
- W2899593875 modified "2023-10-18" @default.
- W2899593875 title "Plum is a novel regulator of synaptic function and muscle size in D. melanogaster" @default.
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- W2899593875 doi "https://doi.org/10.1101/463885" @default.
- W2899593875 hasPublicationYear "2018" @default.
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