Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899638604> ?p ?o ?g. }
- W2899638604 endingPage "107" @default.
- W2899638604 startingPage "97" @default.
- W2899638604 abstract "Our current understanding of the biophysicochemical interactions at nano-bio interfaces is still very limited. Surface plasmon resonance (SPR) is a powerful tool for understanding the real-time kinetics of protein binding on the surface of nanoparticles (NPs) but has been least exploited for this purpose. In this study, we demonstrated the interaction of negatively charged poly lactic-co-glycolic acid (PLGA) NPs and positively charged chitosan oligosaccharide (COS)-coated PLGA NPs with two model proteins, namely bovine serum albumin (BSA) and hen egg white lysozyme (LYZ), at the physiological pH of 7.4. Various biophysical characterization techniques were employed to elucidate the influence of surface charge of NPs on protein interaction. SPR investigations revealed the binding affinity and binding kinetics involved in nanoparticle-protein interactions. These results confirmed that the affinity of both types of NPs towards positively charged LYZ was much greater than that for negatively charged BSA, which was also in accordance with the results of the adsorption studies. Our results demonstrate that the surface properties of the interacting species play a dominant role during protein-nanoparticle interactions, apart from the net charge on their individual surfaces. The information obtained from this study adds significant value to the biophysicochemical toolbox for characterization of nano-bio interactions." @default.
- W2899638604 created "2018-11-16" @default.
- W2899638604 creator A5002884335 @default.
- W2899638604 creator A5009078440 @default.
- W2899638604 creator A5072261395 @default.
- W2899638604 creator A5074321842 @default.
- W2899638604 creator A5074344829 @default.
- W2899638604 date "2019-02-01" @default.
- W2899638604 modified "2023-10-18" @default.
- W2899638604 title "Understanding the nano-bio interactions using real-time surface plasmon resonance tool" @default.
- W2899638604 cites W1238203966 @default.
- W2899638604 cites W1486875326 @default.
- W2899638604 cites W1504792186 @default.
- W2899638604 cites W1548751297 @default.
- W2899638604 cites W1650319068 @default.
- W2899638604 cites W1971375143 @default.
- W2899638604 cites W1980596524 @default.
- W2899638604 cites W1981793606 @default.
- W2899638604 cites W1982106711 @default.
- W2899638604 cites W1991659188 @default.
- W2899638604 cites W2000755721 @default.
- W2899638604 cites W2003090882 @default.
- W2899638604 cites W2005986251 @default.
- W2899638604 cites W2018340655 @default.
- W2899638604 cites W2020398834 @default.
- W2899638604 cites W2021876818 @default.
- W2899638604 cites W2023409962 @default.
- W2899638604 cites W2032496099 @default.
- W2899638604 cites W2037525645 @default.
- W2899638604 cites W2037846869 @default.
- W2899638604 cites W2041075563 @default.
- W2899638604 cites W2041164141 @default.
- W2899638604 cites W2045942255 @default.
- W2899638604 cites W2046527344 @default.
- W2899638604 cites W2051361096 @default.
- W2899638604 cites W2054981131 @default.
- W2899638604 cites W2057910069 @default.
- W2899638604 cites W2058830685 @default.
- W2899638604 cites W2061726838 @default.
- W2899638604 cites W2066685510 @default.
- W2899638604 cites W2070698249 @default.
- W2899638604 cites W2071062657 @default.
- W2899638604 cites W2079094085 @default.
- W2899638604 cites W2084737773 @default.
- W2899638604 cites W2089716915 @default.
- W2899638604 cites W2104017463 @default.
- W2899638604 cites W2134557946 @default.
- W2899638604 cites W2335577615 @default.
- W2899638604 cites W2338429926 @default.
- W2899638604 cites W2460217584 @default.
- W2899638604 cites W2601524347 @default.
- W2899638604 cites W2602584705 @default.
- W2899638604 cites W2735015468 @default.
- W2899638604 cites W2767262629 @default.
- W2899638604 cites W2887179428 @default.
- W2899638604 cites W2890287831 @default.
- W2899638604 doi "https://doi.org/10.1016/j.ijbiomac.2018.11.039" @default.
- W2899638604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30419326" @default.
- W2899638604 hasPublicationYear "2019" @default.
- W2899638604 type Work @default.
- W2899638604 sameAs 2899638604 @default.
- W2899638604 citedByCount "10" @default.
- W2899638604 countsByYear W28996386042019 @default.
- W2899638604 countsByYear W28996386042020 @default.
- W2899638604 countsByYear W28996386042021 @default.
- W2899638604 countsByYear W28996386042022 @default.
- W2899638604 countsByYear W28996386042023 @default.
- W2899638604 crossrefType "journal-article" @default.
- W2899638604 hasAuthorship W2899638604A5002884335 @default.
- W2899638604 hasAuthorship W2899638604A5009078440 @default.
- W2899638604 hasAuthorship W2899638604A5072261395 @default.
- W2899638604 hasAuthorship W2899638604A5074321842 @default.
- W2899638604 hasAuthorship W2899638604A5074344829 @default.
- W2899638604 hasConcept C106847996 @default.
- W2899638604 hasConcept C121332964 @default.
- W2899638604 hasConcept C12554922 @default.
- W2899638604 hasConcept C147789679 @default.
- W2899638604 hasConcept C148898269 @default.
- W2899638604 hasConcept C150394285 @default.
- W2899638604 hasConcept C155672457 @default.
- W2899638604 hasConcept C171250308 @default.
- W2899638604 hasConcept C185592680 @default.
- W2899638604 hasConcept C192562407 @default.
- W2899638604 hasConcept C2776966407 @default.
- W2899638604 hasConcept C2779732960 @default.
- W2899638604 hasConcept C2780165375 @default.
- W2899638604 hasConcept C2780358262 @default.
- W2899638604 hasConcept C43617362 @default.
- W2899638604 hasConcept C55493867 @default.
- W2899638604 hasConcept C62520636 @default.
- W2899638604 hasConcept C86803240 @default.
- W2899638604 hasConcept C86807702 @default.
- W2899638604 hasConcept C88001094 @default.
- W2899638604 hasConceptScore W2899638604C106847996 @default.
- W2899638604 hasConceptScore W2899638604C121332964 @default.
- W2899638604 hasConceptScore W2899638604C12554922 @default.
- W2899638604 hasConceptScore W2899638604C147789679 @default.
- W2899638604 hasConceptScore W2899638604C148898269 @default.