Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899650821> ?p ?o ?g. }
- W2899650821 endingPage "4634" @default.
- W2899650821 startingPage "4622" @default.
- W2899650821 abstract "The chronic inflammatory process underlying inflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, derives from the interplay of several components in a genetically susceptible host. These components include environmental elements and gut microbiota a dysbiosis. For decades, immune abnormalities have been investigated as critically important in IBD pathogenesis, and attempts to develop effective therapies have predominantly targeted the immune system. Nevertheless, immune events represent only one of the constituents contributing to IBD pathogenesis within the context of the complex cellular and molecular network underlying chronic intestinal inflammation. These factors need to be appreciated within the milieu of non-immune components. Damage-associated molecular patterns (DAMPs), which are essentially endogenous stress proteins expressed or released as a result of cell or tissue damage, have been shown to act as direct pro-inflammatory mediators. Excessive or persistent signalling mediated by such molecules can underlie several chronic inflammatory disorders, including IBD. The release of endogenous DAMPs amplifies the inflammatory response driven by immune and non-immune cells and promotes epigenetic reprogramming in IBD. The effects determine pathologic changes, which may sustain chronic intestinal inflammation and also underlie specific disease phenotypes. In addition to highlighting the potential use of DAMPs such as calprotectin as biomarkers, research on DAMPs may reveal novel mechanistic associations in IBD pathogenesis and is expected to uncover putative therapeutic targets." @default.
- W2899650821 created "2018-11-16" @default.
- W2899650821 creator A5002164805 @default.
- W2899650821 creator A5004694954 @default.
- W2899650821 creator A5027011220 @default.
- W2899650821 creator A5076177981 @default.
- W2899650821 date "2018-11-07" @default.
- W2899650821 modified "2023-10-14" @default.
- W2899650821 title "Damage-associated molecular patterns in inflammatory bowel disease: From biomarkers to therapeutic targets" @default.
- W2899650821 cites W1033462468 @default.
- W2899650821 cites W1513110975 @default.
- W2899650821 cites W1606491845 @default.
- W2899650821 cites W1771440738 @default.
- W2899650821 cites W1839129697 @default.
- W2899650821 cites W1906612937 @default.
- W2899650821 cites W1968955229 @default.
- W2899650821 cites W1969485182 @default.
- W2899650821 cites W1969929840 @default.
- W2899650821 cites W1972204333 @default.
- W2899650821 cites W1973399759 @default.
- W2899650821 cites W1974033611 @default.
- W2899650821 cites W1980215718 @default.
- W2899650821 cites W1982754708 @default.
- W2899650821 cites W1983589036 @default.
- W2899650821 cites W1987329859 @default.
- W2899650821 cites W1992446264 @default.
- W2899650821 cites W1994190235 @default.
- W2899650821 cites W1997246021 @default.
- W2899650821 cites W2002107602 @default.
- W2899650821 cites W2002148635 @default.
- W2899650821 cites W2004261397 @default.
- W2899650821 cites W2006690805 @default.
- W2899650821 cites W2006712244 @default.
- W2899650821 cites W2006960578 @default.
- W2899650821 cites W2007035508 @default.
- W2899650821 cites W2007808963 @default.
- W2899650821 cites W2008960002 @default.
- W2899650821 cites W2009105615 @default.
- W2899650821 cites W2009672148 @default.
- W2899650821 cites W2009710456 @default.
- W2899650821 cites W2011002068 @default.
- W2899650821 cites W2014379411 @default.
- W2899650821 cites W2014475853 @default.
- W2899650821 cites W2015747379 @default.
- W2899650821 cites W2016219300 @default.
- W2899650821 cites W2018983895 @default.
- W2899650821 cites W2020203901 @default.
- W2899650821 cites W2021208119 @default.
- W2899650821 cites W2021754448 @default.
- W2899650821 cites W2021863432 @default.
- W2899650821 cites W2022548397 @default.
- W2899650821 cites W2029650748 @default.
- W2899650821 cites W2034716576 @default.
- W2899650821 cites W2035274828 @default.
- W2899650821 cites W2038956437 @default.
- W2899650821 cites W2042851093 @default.
- W2899650821 cites W2045295282 @default.
- W2899650821 cites W2045799105 @default.
- W2899650821 cites W2046551442 @default.
- W2899650821 cites W2050093406 @default.
- W2899650821 cites W2050488981 @default.
- W2899650821 cites W2052708139 @default.
- W2899650821 cites W2054378007 @default.
- W2899650821 cites W2059217150 @default.
- W2899650821 cites W2059494963 @default.
- W2899650821 cites W2064270120 @default.
- W2899650821 cites W2064557077 @default.
- W2899650821 cites W2066327704 @default.
- W2899650821 cites W2070165435 @default.
- W2899650821 cites W2070290315 @default.
- W2899650821 cites W2071475760 @default.
- W2899650821 cites W2071649876 @default.
- W2899650821 cites W2071675524 @default.
- W2899650821 cites W2077929572 @default.
- W2899650821 cites W2080950505 @default.
- W2899650821 cites W2081536457 @default.
- W2899650821 cites W2081810806 @default.
- W2899650821 cites W2082814058 @default.
- W2899650821 cites W2083928080 @default.
- W2899650821 cites W2084452809 @default.
- W2899650821 cites W2087708034 @default.
- W2899650821 cites W2089390755 @default.
- W2899650821 cites W2089491627 @default.
- W2899650821 cites W2090071444 @default.
- W2899650821 cites W2094833786 @default.
- W2899650821 cites W2095518569 @default.
- W2899650821 cites W2104160845 @default.
- W2899650821 cites W2104414795 @default.
- W2899650821 cites W2104722369 @default.
- W2899650821 cites W2105458866 @default.
- W2899650821 cites W2105865292 @default.
- W2899650821 cites W2107587038 @default.
- W2899650821 cites W2110115488 @default.
- W2899650821 cites W2112042684 @default.
- W2899650821 cites W2113320375 @default.
- W2899650821 cites W2116797415 @default.
- W2899650821 cites W2120199644 @default.
- W2899650821 cites W2122621644 @default.