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- W2899664088 endingPage "3508" @default.
- W2899664088 startingPage "3508" @default.
- W2899664088 abstract "Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of illnesses, such as adult T-cell leukemia/lymphoma, myelopathy/tropical spastic paraparesis (a neurodegenerative disorder), and other diseases. Therefore, HTLV-1 infection is a serious public health concern. Currently, diseases caused by HTLV-1 cannot be prevented or cured. Hence, there is a pressing need to comprehensively understand the mechanisms of HTLV-1 infection and intervention in host cell physiology. HTLV-1-encoded non-structural proteins that reside and function in the cellular membranes are of particular interest, because they alter cellular components, signaling pathways, and transcriptional mechanisms. Summarized herein is the current knowledge about the functions of the membrane-associated p8I, p12I, and p13II regulatory non-structural proteins. p12I resides in endomembranes and interacts with host proteins on the pathways of signal transduction, thus preventing immune responses to the virus. p8I is a proteolytic product of p12I residing in the plasma membrane, where it contributes to T-cell deactivation and participates in cellular conduits, enhancing virus transmission. p13II associates with the inner mitochondrial membrane, where it is proposed to function as a potassium channel. Potassium influx through p13II in the matrix causes membrane depolarization and triggers processes that lead to either T-cell activation or cell death through apoptosis." @default.
- W2899664088 created "2018-11-16" @default.
- W2899664088 creator A5010730078 @default.
- W2899664088 date "2018-11-08" @default.
- W2899664088 modified "2023-10-17" @default.
- W2899664088 title "Non-Structural Proteins from Human T-cell Leukemia Virus Type 1 in Cellular Membranes—Mechanisms for Viral Survivability and Proliferation" @default.
- W2899664088 cites W1482769266 @default.
- W2899664088 cites W1525646048 @default.
- W2899664088 cites W1531198730 @default.
- W2899664088 cites W1579427183 @default.
- W2899664088 cites W1596304334 @default.
- W2899664088 cites W1606216715 @default.
- W2899664088 cites W1659625814 @default.
- W2899664088 cites W1759848056 @default.
- W2899664088 cites W1789872954 @default.
- W2899664088 cites W1945253873 @default.
- W2899664088 cites W1965734808 @default.
- W2899664088 cites W1969286567 @default.
- W2899664088 cites W1972994253 @default.
- W2899664088 cites W1974313653 @default.
- W2899664088 cites W1974712482 @default.
- W2899664088 cites W1974783904 @default.
- W2899664088 cites W1979637191 @default.
- W2899664088 cites W1983867919 @default.
- W2899664088 cites W1992814804 @default.
- W2899664088 cites W1992921721 @default.
- W2899664088 cites W1992967227 @default.
- W2899664088 cites W1994602933 @default.
- W2899664088 cites W1998392122 @default.
- W2899664088 cites W1998976463 @default.
- W2899664088 cites W2000493448 @default.
- W2899664088 cites W2000737156 @default.
- W2899664088 cites W2002974485 @default.
- W2899664088 cites W2003756602 @default.
- W2899664088 cites W2008383971 @default.
- W2899664088 cites W2008757391 @default.
- W2899664088 cites W2013436183 @default.
- W2899664088 cites W2015197085 @default.
- W2899664088 cites W2018826999 @default.
- W2899664088 cites W2024282024 @default.
- W2899664088 cites W2024639690 @default.
- W2899664088 cites W2024949533 @default.
- W2899664088 cites W2025200528 @default.
- W2899664088 cites W2026570257 @default.
- W2899664088 cites W2027818943 @default.
- W2899664088 cites W2028379639 @default.
- W2899664088 cites W2030109931 @default.
- W2899664088 cites W2030511374 @default.
- W2899664088 cites W2031894089 @default.
- W2899664088 cites W2034727829 @default.
- W2899664088 cites W2035371681 @default.
- W2899664088 cites W2036145275 @default.
- W2899664088 cites W2038365894 @default.
- W2899664088 cites W2038816853 @default.
- W2899664088 cites W2042704418 @default.
- W2899664088 cites W2049415783 @default.
- W2899664088 cites W2050758185 @default.
- W2899664088 cites W2052700342 @default.
- W2899664088 cites W2054898011 @default.
- W2899664088 cites W2056106902 @default.
- W2899664088 cites W2058350611 @default.
- W2899664088 cites W2066492659 @default.
- W2899664088 cites W2066872651 @default.
- W2899664088 cites W2067661362 @default.
- W2899664088 cites W2069438135 @default.
- W2899664088 cites W2076598575 @default.
- W2899664088 cites W2078089821 @default.
- W2899664088 cites W2078533052 @default.
- W2899664088 cites W2079611331 @default.
- W2899664088 cites W2079694745 @default.
- W2899664088 cites W2079767086 @default.
- W2899664088 cites W2080709615 @default.
- W2899664088 cites W2083780439 @default.
- W2899664088 cites W2084470763 @default.
- W2899664088 cites W2086143621 @default.
- W2899664088 cites W2091485610 @default.
- W2899664088 cites W2094343556 @default.
- W2899664088 cites W2094831592 @default.
- W2899664088 cites W2099019634 @default.
- W2899664088 cites W2100815929 @default.
- W2899664088 cites W2105379326 @default.
- W2899664088 cites W2111164137 @default.
- W2899664088 cites W2115382610 @default.
- W2899664088 cites W2116076032 @default.
- W2899664088 cites W2116379047 @default.
- W2899664088 cites W2123679031 @default.
- W2899664088 cites W2125302766 @default.
- W2899664088 cites W2125475184 @default.
- W2899664088 cites W2130212947 @default.
- W2899664088 cites W2130621814 @default.
- W2899664088 cites W2139607759 @default.
- W2899664088 cites W2141706974 @default.
- W2899664088 cites W2143522905 @default.
- W2899664088 cites W2145106676 @default.
- W2899664088 cites W2145626047 @default.
- W2899664088 cites W2145827111 @default.
- W2899664088 cites W2148343072 @default.
- W2899664088 cites W2148963137 @default.